BROMHEXINE


DrugBank ID: db09019
DrugCentral: bromhexine
Synonymous :3,5-dibromo-n(alpha)-cyclohexyl-n(alpha)-methyltoluene-alpha-2-diamine | bromexina | bromhexina | bromhexine | bromhexinum | n-cyclohexyl-n-methyl-(2-amino-3,5-dibrombenzyl)amine



Drug Sentece Context


Table 1. Analysis of context sentence of bromhexine gene in 21 abstracts.

pmid sentence
32458206 Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. […] We propose the use of bromhexine as a prophylactic and treatment. […] We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment.
32741259 Camostat and bromhexine are known TMPRSS2 inhibitor drugs, hence these were used as control molecules throughout the study.
32824674 Clinical studies on TMPRSS2 inhibitors, such as camostat, nafamostat, and bromhexine, are ongoing.
32881359 This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clinical efficacy and safety.
32925756 Bromhexine hydrochloride tablets may be effective in the treatment of Coronavirus disease 2019 (COVID-19) in children. […] This study will further evaluate the efficacy and safety of bromhexine hydrochloride tablets in the treatment of COVID-19 in children. […] This systematic review will evaluate the current status of bromhexine hydrochloride in the treatment of COVID-19 in children, to evaluate its efficacy and safety. […] This study will provide the latest evidence for evaluating the efficacy and safety of bromhexine hydrochloride in the treatment of COVID-19 in children.
32972339 Both available evidence as well as hypotheses are discussed, with emphasis on drugs which are approved for other indications such as bromhexine, ammonium chloride, nafamostat, camostat, tranexamic acid, epsilon amino-caproic acid, chloroquine, ulinastatin, aprotinin and anticoagulant drugs.
32983936 Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. […] The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19. […] They were randomized to either the treatment with the bromhexine group or the control group, in a 1:1 ratio with 39 patients in each arm. […] Standard therapy was used in both groups and those patients in the treatment group received oral bromhexine 8 mg three times a day additionally. […] 5, P = 0.027) in the bromhexine treated group compared to the standard group. […] Conclusion: The early administration of oral bromhexine reduces the ICU transfer, intubation, and the mortality rate in patients with COVID-19.