AURANOFIN


DrugBank ID: db00995
DrugCentral: auranofin
Synonymous :(1-thio-beta-d-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate | 2,3,4,6-tetra-o-acetyl-1-thio-beta-d-glucopyranosato-s (triethylphosphine)gold | auranofin | auranofina | auranofine | auranofinum | triethylphosphine gold



Drug Sentece Context


Table 1. Analysis of context sentence of auranofin gene in 6 abstracts.

pmid sentence
32442105 Herein, we report that the FDA-approved drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro molar concentration. […] Treatment of cells with auranofin resulted in a 95% reduction in the viral RNA at 48 h after infection. […] Auranofin treatment dramatically reduced the expression of SARS-COV-2-induced cytokines in human cells. […] These data indicate that auranofin could be a useful drug to limit SARS-CoV-2 infection and associated lung injury due to its antiviral, anti-inflammatory and anti-reactive oxygen species (ROS) properties. […] Further animal studies are warranted to evaluate the safety and efficacy of auranofin for the management of SARS-COV-2 associated disease.
32915473 Herein, we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two relevant drug targets of severe acute respiratory syndrome coronaviruses (SARS-CoV).
32915656 To this respect, the gold drug auranofin seems a promising candidate, but some other clinically established metal compounds are worthy of a careful evaluation as well.
33030464 Classical compounds such as CTC-96 and auranofin are discussed in depth, as pillars for future metallodrug development.