ATP


DrugBank ID: db00171
DrugCentral: atp
Synonymous :adenosine 5’-triphosphate | adenosine triphosphate | adenosine-5’-triphosphate | atp



Drug Sentece Context


Table 1. Analysis of context sentence of atp gene in 9 abstracts.

pmid sentence
32094225 The triphosphate form of the inhibitor (RDV-TP) competes with its natural counterpart ATP. […] Of note, the selectivity value for RDV-TP obtained here with a steady-state approach suggests that it is more efficiently incorporated than ATP and two other nucleotide analogs.
32284326 A unique property of RDV-TP is its high selectivity over incorporation of its natural nucleotide counterpart ATP.
32314850 PDC drives mitochondrial conversion of pyruvate to acetyl-coenzyme A (acetyl-CoA), thereby increasing the tricarboxylic acid cycle, oxidative phosphorylation, and ATP production.
32388390 In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent or fight off COVID-19.
32461321 PEDV nsp14 can efficiently methylate RNA substrates with various lengths in both neutral and alkaline pH environment, and can methylate cap analogs (GpppA and GpppG) and single nucleotide GTP but not ATP, CTP, or UTP.
32519892 PANX1 channels passively flux ATP (predominantly), multiple metabolites, and likely other small anions.
32521159 We then built a putative preinsertion binding structure by aligning the remdesivir + RdRp complex to the ATP bound poliovirus RdRp without the RNA template. […] The relative binding free energy between remdesivir and ATP was calculated to be -2.80 ± 0.84 kcal/mol, where remdesivir bound much stronger to SARS-CoV-2 RdRp than the natural substrate ATP. […] The ∼100-fold improvement in the Kd from remdesivir over ATP indicates an effective replacement of ATP in blocking of the RdRp preinsertion site.
32579049 This characteristic can represent an important differential to change this process in the event of an imbalance in this system, through the photobiomodulation to increase the production of adenosine triphosphate (ATP) using red and near-infrared radiation (R-NIR) and vitamin D using ultraviolet B (UVB) radiation. […] The light is also absorbed by cytochrome c oxidase in the R-NIR region, with a consequent increase in electron transport, regulating enzyme activity and resulting in a significant increase of oxygen rate consumption by mitochondria, increasing ATP production. Conclusions: The most favorable range of optical radiation to operate in this system is between R-NIR region, in which cytochrome c oxidase and porphyrin present absorption peaks centered at 640 nm and HbO2 with absorption peak centered at 900 nm.
32590324 Upon infection or cell damage, high amounts of adenosine triphosphate (ATP) are released from damaged cells, which serve as mediators of inflammation through purinergic cell surface receptor signaling. […] As a protective mechanism to prevent excessive damage to host tissue, adenosine counteracts ATP’s effects by adenosine receptor stimulation to suppress the pro-inflammatory response.