APREMILAST


DrugBank ID: db05676
DrugCentral: apremilast
Synonymous :apremilast | aprémilast | apremilastum | n-{2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1h-isoindol-4-yl}acetamide



Drug Sentece Context


Table 1. Analysis of context sentence of apremilast gene in 2 abstracts.

pmid sentence
32385859 Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur.
32458536 Apremilast, acitretin and dupilumab, have favorable safety data, and may be safely initiated and continued in uninfected patients.
32475036 Apremilast is a recently approved drug, belonging to the small molecule phosphodiesterase 4 inhibitors, whose optimal safety and efficacy profile is somewhat affected by slow activity rate in clinical trials. […] Moreover, the observation period includes the Italian outbreak of COVID-19 epidemic, and further information on apremilast safety are provided, no one of the patients having stopped treatment. […] In such a critical period, the apremilast satisfactory speed of therapeutic response in a real-world setting has further strengthens patient’s compliance to remain safely at home, which is the best strategy to limit contagion.