APREMILAST


DrugBank ID: db05676
DrugCentral: apremilast
Synonymous :apremilast | aprémilast | apremilastum | n-{2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1h-isoindol-4-yl}acetamide



Drug Sentece Context


Table 1. Analysis of context sentence of apremilast gene in 7 abstracts.

pmid sentence
32385859 Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur.
32458536 Apremilast, acitretin and dupilumab, have favorable safety data, and may be safely initiated and continued in uninfected patients.
32475036 Apremilast is a recently approved drug, belonging to the small molecule phosphodiesterase 4 inhibitors, whose optimal safety and efficacy profile is somewhat affected by slow activity rate in clinical trials. […] Moreover, the observation period includes the Italian outbreak of COVID-19 epidemic, and further information on apremilast safety are provided, no one of the patients having stopped treatment. […] In such a critical period, the apremilast satisfactory speed of therapeutic response in a real-world setting has further strengthens patient’s compliance to remain safely at home, which is the best strategy to limit contagion.
32618402 The patient infected with COVID-19 on apremilast and the one on apremilast with infected spouse showed the best safety profile and mildest symptoms. […] Even though more clinical data are yet needed to draw strong conclusions, apremilast could be a safer alternative for dermatology and rheumatology patients in case of clinically important active infection.
32931985 Available data suggest no increased frequency or risk of respiratory viral events with NSAIDs, hydroxychloroquine, sulfasalazine, methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide, or apremilast.