AMITRIPTYLINE
DrugBank ID: db00321
DrugCentral: amitriptyline
Synonymous :10,11-dihydro-5-(γ-dimethylaminopropylidene)-5h-dibenzo(a,d)cycloheptene | 10,11-dihydro-n,n-dimethyl-5h-dibenzo(a,d)heptalene-δ5,γ-propylamine | 3-(10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamine | 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimethylpropan-1-amine | 5-(3-dimethylaminopropylidene)-10,11-dihydro-5h-dibenzo(a,d)cycloheptatriene | 5-(3-dimethylaminopropylidene)-10,11-dihydro-5h-dibenzo(a,d)cycloheptene | 5-(γ-dimethylaminopropylidene)-5h-dibenzo[a,d][1,4]cycloheptadiene | amitriptilina | amitriptylin | amitriptyline | amitriptylinum
Drug Sentece Context
Table 1. Analysis of context sentence of amitriptyline gene in 2 abstracts.
| pmid | sentence |
|---|---|
| 33163980 | Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV) pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 spike), a bona fide system mimicking SARS-CoV-2 infection. […] Treating volunteers with a low dose of amitriptyline prevents infection of freshly isolated nasal epithelial cells with pp-VSV-SARS-CoV-2 spike. […] The data justify clinical studies investigating whether amitriptyline, a safe drug used clinically for almost 60 years, or other antidepressants that functionally block acid sphingomyelinase prevent SARS-CoV-2 infection. |