AMBROXOL
DrugBank ID: db06742
DrugCentral: ambroxol
Synonymous :ambroxolum | bisolvon metabolite viii | bromhexine metabolite viii | bromhexine-metabolite viii | cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (e)- | n-(2-amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol | n-(2-amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol | trans-4-((2-amino-3,5-dibromobencil)amino)ciclohexanol | trans-4-((2-amino-3,5-dibromobenzyl)amine)cyclohexanol | trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol
Drug Sentece Context
Table 1. Analysis of context sentence of ambroxol gene in 6 abstracts.
| pmid | sentence |
|---|---|
| 32741259 | Based on better dock score, binding-free energy and binding interactions compared to the control molecules, six molecules (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) were found to be promising against the TMPRSS2. |
| 33045350 | This paper highlights the potential of azithromycin and ambroxol to treat COVID-19. […] Azithromycin and ambroxol share lysosomotropic characteristics, i.e. they penetrate and accumulate inside the late endosomes and lysosomes and may possibly interfere with multiplication of the virus inside cells. […] Ambroxol has a proven antiviral effect and a unique stimulatory action on the secretion of surfactant by alveolar type II cells, the main target of SARS-CoV-2. |
| 33102461 | This hypothesis proposes aerosolized surfactant delivery taking the optimal dosing and coating costs into account along with co-delivery of ambroxol to provide synergistic benefits. […] Ambroxol is reported to have anti-inflammatory, -oxidant, -viral, and -bacterial activities and has a direct impact on the production and secretion of the surfactant from the alveolar Type 2 cells. […] If aerosolized, atomized, or nebulized in the form of ambroxol-loaded phospholipid nanovesicles at the early stages of ARDS, depleted surfactant levels may be reinstated and surfactant turnover can be initiated and maintained. […] In conclusion, the surfactant-ambroxol co-aerosolized intervention approach hypothesized here has implications reaching to clinical and pharmaceutical translation worldwide. |
| 33181718 | In addition, we found that the application rates of large doses of ambroxol (P = .043) and prone-position drainage (P = .037) were relatively high in COVID-19 patients with good prognoses, suggesting that the early application of large doses of expectorant drugs and prone-position drainage in COVID-19 patients may avoid progression to critical illness and improve the prognosis. |
| 33290446 | Nine patients were prescribed systemic prednisone and nasal irrigation with betamethasone, ambroxol and rinazine for 15 days. |