DrugBank ID: db00915
DrugCentral: amantadine
Synonymous :1-adamantanamine | 1-adamantylamine | 1-aminoadamantane | amantadina | amantadine | amantadinum | amantidine | aminoadamantane

Drug Sentece Context

Table 1. Analysis of context sentence of amantadine gene in 5 abstracts.

pmid sentence
32361028 One of the top significant results shown to downregulate the expression of the CTSL gene is amantadine (10uM). […] Amantadine was approved by the US Food and Drug Administration in 1968 as a prophylactic agent for influenza and later for Parkinson’s disease. […] Amantadine in addition to downregulating CTSL appears to further disrupt lysosomal pathway, hence, interfering with the capacity of the virus to replicate. […] We hypothesize that amantadine could decrease the viral load in SARS-CoV-2 positive patients and as such it may serve as a potent therapeutic decreasing the replication and infectivity of the virus likely leading to better clinical outcomes. […] Clinical studies will be needed to examine the therapeutic utility of amantadine in COVID-19 infection.
32361100 We are proposing amantadine as a drug that can be used to mitigate the effects of the virus. […] It is demonstrated by docking models how amantadine can exert its action on Coronavirus viroporin E.
32388458 They were receiving treatment with either amantadine (n=15) or memantine (n=7) in stable registered doses.
32436995 Memantine and related adamantine such as amantadine, which is utilized in Parkinson’s disease and influenza, may have some anti-viral potential as well.
32571606 In the absence of a vaccine or medication to help prevent or decrease the effects of the disease, we suggest that amantadine may reduce the effects of COVID-19.