DrugBank ID: db01430
DrugCentral: almitrine
Synonymous :2,4-bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine | almitrina | almitrine | almitrinum

Drug Sentece Context

Table 1. Analysis of context sentence of almitrine gene in 11 abstracts.

pmid sentence
32835274 Almitrine infusion allowed rapid enhancement of right ventricular function as well as improvement in oxygenation.
33093279 The present study assessed the effect of almitrine, a selective pulmonary vasoconstrictor, on arterial oxygenation in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome. […] Data focused on clinicobiological features, ventilator settings, therapeutics, outcomes, and almitrine-related adverse events. […] Almitrine was considered in patients with severe hypoxemia (Pao2/Fio2 ratio < 150 mm Hg) in addition to the recommended therapies, at an hourly IV delivery of 10 μg/kg/min. […] Comparative blood gases were done before starting almitrine trial and immediately after the end of the infusion. […] A positive response to almitrine was defined by an increase of Pao2/Fio2 ratio greater than or equal to 20% at the end of the infusion. […] Thirty-two patients with acute respiratory distress syndrome received an almitrine infusion trial. […] In most cases, almitrine was infused in combination with inhaled nitric oxide (75%). […] Almitrine infusion improved oxygenation in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome without adverse effects. […] In a multistep clinical approach to manage severe hypoxemia in this population, almitrine could be an interesting therapeutic option to counteract the loss of hypoxic pulmonary vasoconstriction and redistribute blood flow away from shunting zones.
33150525 This study aimed to evaluate the capacity of inhaled nitric oxide (iNO)-almitrine combination to restore oxygenation in severe COVID-19 ARDS (C-ARDS) patients. ratio). ratio varied from 102 [89-134] mmHg at baseline, to 124 [108-146] mmHg after iNO (p = 0.13) and 180 [132-206] mmHg after iNO and almitrine (p < 0.01). […] We found no correlation between the increase in oxygenation caused by iNO-almitrine combination and that caused by proning. […] In this pilot study of severe C-ARDS patients, iNO-almitrine combination was associated with rapid and significant improvement of oxygenation.
33191206 These drugs include fingolimod, colchicine, N4-hydroxycytidine, remdesivir, methylprednisone, oseltamivir, icatibant, perphanizine, viracept, emetine, homoharringtonine, aloxistatin, ribavirin, valrubicin, famotidine, almitrine, amprenavir, hesperidin, biorobin, cromolyn sodium, and antibodies- tocilzumab and sarilumab.