ALISKIREN

DrugBank ID: db09026
DrugCentral: aliskiren
Synonymous :aliskiren | aliskireno

Drug Sentece Context

Table 1. Analysis of context sentence of aliskiren gene in 6 abstracts.

pmid	sentence
32340096	Objective: To explore the feasibility of direct renin inhibitor aliskiren for the treatment of severe patients of COVID-19 with hypertension. Methods: A retrospective case analysis of effectiveness and safety of aliskiren treatment to lower blood pressure in three severe and one critically ill patients of COVID-19 with hypertension. Results: Four patients, two males and two females, with an average age of 78 years (66-87 years), were referred to hospital mainly because of respiratory symptoms. […] After admission, ACEI or ARB were discontinued, one patient with heart failure patient was treated by aliskiren combined with diuretic; 3 patients were treated with aliskiren combined with CCB. […] Two patients were stopped to use CCB due to low blood pressure after 1 to 2 weeks of using CCB and aliskiren. […] On the basis of comprehensive therapy combined with antiviral and oxygenation treatment, aliskiren antihypertensive treatment was taken for three to four weeks. […] The condition improved, and all patients had reached the discharge standard and were discharged. Conclusion: Our preliminary clinical data shows that aliskiren’s antihypertensive therapy is effective and safe for severe COVID-19 patients complicated with hypertension. […] Further clinical aliskiren therapy study is required with more COVID-19 patients.. 目的：探索直接肾素抑制剂阿利吉伦用于重型新型冠状病毒肺炎(COVID-19)合并高血压患者治疗的可行性。