transient receptor potential cation channel subfamily A member 1
Gene Context Sentence
Table 2. Analysis of context sentence of TRPA1 gene in 4 abstracts.
|PMID||Gene Context Sentence|
|33292691||Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1.|
|33352565||Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. […] It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19.|
|33425204||It is likely that the fast onset of action is mediated through the TRPA1 channel.|
|33567446||In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. […] TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. […] TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. […] TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. […] Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. […] The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence.|