ribonucleic acid export 1
Gene Context Sentence
Table 2. Analysis of context sentence of RAE1 gene in 2 abstracts.
|PMID||Gene Context Sentence|
|33097660||We found that SARS-CoV-2 Orf6 localizes at the nuclear pore complex (NPC) and directly interacts with Nup98-Rae1 via its C-terminal domain to impair docking of cargo-receptor (karyopherin/importin) complex and disrupt nuclear import. […] In addition, we show that a methionine-to-arginine substitution at residue 58 impairs Orf6 binding to the Nup98-Rae1 complex and abolishes its IFN antagonistic function. […] All together our data unravel a mechanism of viral antagonism in which a virus hijacks the Nup98-Rae1 complex to overcome the antiviral action of IFN.|
|33360543||We found that ORF6 protein disrupted nuclear rim staining of nucleoporins RAE1 and NUP98.|