HLA-A
major histocompatibility complex, class I, A
Gene Context Sentence
Table 2. Analysis of context sentence of HLA-A gene in 21 abstracts.
| PMID | Gene Context Sentence |
|---|---|
| 32295479 | After predicting and evaluating of the third structure of the protein candidate, the best 3 D predicted model was applied for docking studies with Toll-like receptor 4 (TLR4) and HLA-A11:01. […] In the next step, molecular dynamics (MD) simulation was used to evaluate the stability of the designed fusion protein with TLR4 and HLA-A11:01 receptors. […] MD studies demonstrated that the NOM-TLR4 and NOM-HLA-A*11:01 docked models were stable during simulation time. In silico evaluation showed that the designed chimeric protein could simultaneously elicit humoral and cell-mediated immune responses. |
| 32424945 | Here, 82 individuals with COVID-19 were genotyped for HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1, and -DPB1 loci using next-generation sequencing. |
| 32475052 | Among the strong HLA binders (IC50 ≤ 50), we uncovered 16 alleles (the top ones being A02:02, B15:03 and DRB101:02) binding more than 1% of peptides derived from all viruses, 9 (top ones including HLA-A68:01, B15:25, C03:02 and DRB107:01) binding all viruses except HIV-1, and 15 (top ones A02:01 and C*14:02) only binding coronaviruses. |
| 32623831 | A bias towards an increased representation of HLA-A26, HLA-DRB115, HLA-DRB110 and DRB111 was also noted but these were either only significant using the UK donor controls, or did not remain significant after correction for multiple tests. […] Likewise, HLA-A02, HLA-B44 and HLA-C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests. |
| 32699345 | We also found that the frequency of several HLA alleles, including HLA-A*11:01, were significantly associated with the fatality rates, although these factors were associated with number of infected cases and not an independent factor to affect fatality rate in each country. |
| 32717807 | Among all the alleles, HLA-A25, B08, B44, B15:01, B51, C01, and C03 showed a positive log-linear correlation with COVID-19 incidence rate fixed on 9 April 2020 in proximity of the national outbreak peak (Pearson’s coefficients between 0.50 and 0.70, p-value < 0.0001), whereas HLA-B14, B18, and B49 showed an inverse log-linear correlation (Pearson’s coefficients between -0.47 and -0.59, p-value < 0.0001). |
| 32759312 | We identified 24 immunogenic epitopes in the SARS-CoV-2 protein S that could interact with 17 different MHC-I alleles (namely, HLA-A01:01; HLA-A02:01; HLA-A11:01; HLA-A24:02; HLA-A68:01; HLA-A23:01; HLA-A26:01; HLA-A30:02; HLA-A31:01; HLA-B07:02; HLA-B51:01; HLA-B35:01; HLA-B44:02; HLA-B35:03; HLA-C05:01; HLA-C07:01 and HLA-C*15:02) in the Brazilian population. |
| 32913053 | Experience with influenza shows that infection primes CD8+ T cell memory to peptides presented by common HLA types like HLA-A2, which enhances recovery and diminishes clinical severity upon reinfection. […] We identified two HLA-A02:01-restricted SARS-CoV-2-specfic CD8+ T cell epitopes, A2/S269-277 and A2/Orf1ab3183-3191 Using peptide-HLA tetramer enrichment, direct ex vivo assessment of A2/S269+CD8+ and A2/Orf1ab3183+CD8+ populations indicated that A2/S269+CD8+ T cells were detected at comparable frequencies (∼1.3 × 10-5) in acute and convalescent HLA-A02:01+ patients. […] These frequencies were higher than those found in uninfected HLA-A*02:01+ donors (∼2.5 × 10-6), but low when compared to frequencies for influenza-specific (A2/M158) and Epstein-Barr virus (EBV)-specific (A2/BMLF1280) (∼1.38 × 10-4) populations. |
| 32933522 | In this study we analysed the regional frequencies for the most common Italian haplotypes from the Italian Bone Marrow Donor Registry (HLA-A, -B, -C and -DRB1 at four-digit level). […] In this study we found that the two most frequent HLA haplotypes in the Italian population, HLA-A:01:01g-B08:01 g-C07:01g-DRB103:01g and HLA-A02.01g-B18.01g-C07.01g-DRB111.04g, had a regional distribution overlapping that of Covid-19 and showed respectively a positive (suggestive of susceptibility) and negative (suggestive of protection) significant correlation with both Covid-19 incidence and mortality. |
| 32988645 | We found a trend to a higher rate of the alleles HLA-A32 (p=0.004) in healthy controls than in COVID-19 patients, and of the alleles HLA-B39 (p=0.02) and HLA-C16 (p=0.02) in COVID-19 patients than in healthy controls; however, all these p-values were not significant after correction for multiple comparisons. […] Logistic regression analysis showed that the presence of certain alleles was associated with higher mortality, such as the allele HLA-A11 after controlling for SOFA (OR=7.693; 95% CI=1.063-55.650; p=0.04) or APACHE-II (OR=11.858; 95% CI=1.524-92.273; p=0.02), the allele HLA-C01 after controlling for SOFA (OR=11.182; 95% CI=1.053-118.700; p=0.04) or APACHE-II (OR=17.604; 95% CI=1.629-190.211; p=0.02), and the allele HLA-DQB104 after controlling for SOFA (OR=9.963; 95% CI=1.235-80.358; p=0.03). |
| 33024578 | Finally, HLA-A*03 restricted 8-mer peptides are found to be shared broadly by human and coronaviridae helicases in functional hotspots, with potential implications for nucleic acid unwinding upon initial infection. |
| 33047883 | We found that a possible association between HLA-A02:01 and an increased risk for COVID-19. […] HLA-A02:01 had a relatively lower capacity to present SARS-CoV-2 antigens compared with other frequent HLA class I molecules, HLA-A11:01 or HLA-A24:02. […] This study suggests that individuals with HLA-A11:01 or HLA-A24:02 genotypes may generate efficiently T-cell-mediated antiviral responses to SARS-CoV-2 compared with HLA-A*02:01. |
| 33085221 | We characterized medication orders, focusing on medications with actionable PGx guidance related to 14 commonly assayed genes (CYP2C19, CYP2C9, CYP2D6, CYP3A5, DPYD, G6PD, HLA-A, HLA-B, IFNL3, NUDT15, SLCO1B1, TPMT, UGT1A1, and VKORC1). |
| 33268522 | For the development of vaccines based on SARS-CoV-2-specific cytotoxic T lymphocytes (CTLs), we attempted to identify HLA-A02:01-restricted CTL epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2. […] Out of 82 peptides predicted on bioinformatics, 54 peptides showed good binding affinities to HLA-A02:01. […] Using HLA-A*02:01 transgenic mice, 18 in 54 peptides were found to be CTL epitopes in the intracellular cytokine staining assay. |
| 33298875 | We identified that the HLA-A11:01, B51:01, and C*14:02 alleles significantly predispose the worst outcome of the patients. |
| 33301503 | We found diverse capacities of S protein specific epitope presentation by different HLA alleles with very limited number of predicted epitopes for HLA-B2705, HLA-B4402 and HLA-B4403 and as high as 132 epitopes for HLA-A6601. |
| 33325143 | Besides, docking analysis showed that the predicted peptide ‘KIADYNYKL’ was closely bound to the HLA-A0201. […] The results of molecular dynamics simulation through GROMACS software showed that ’HLA-A0201~peptide’ complex was very stable. |
| 33343579 | The extended haplotype HLA-A02:05, B58:01, C07:01, DRB103:01 [OR 0.1 (95% CI 0-0.6), Pc = 0.015] was absent in all 182 patients, while the HLA-C04:01 allele and the three-loci haplotype HLA-A30:02, B14:02, C08:02 [OR 3.8 (95% CI 1.8-8.1), Pc = 0.025] were more frequently represented in patients than controls. […] The data emerging from our study suggest that the extended haplotype HLA-A02:05, B58:01, C07:01, DRB103:01 has a protective effect against SARS-CoV-2 infection in the Sardinian population. |
| 33361777 | To help achieve these aims, we profiled the entire SARS-CoV-2 proteome across the most frequent 100 HLA-A, HLA-B and HLA-DR alleles in the human population, using host-infected cell surface antigen presentation and immunogenicity predictors from the NEC Immune Profiler suite of tools, and generated comprehensive epitope maps. |
| 33403186 | Methods To clarify the relationship between HLA class I and the severity rate, the binding repertoires of each HLA class I allele to SARS-CoV-2 peptides and the allele frequencies of HLA-A, -B, and -A/B haplotypes in each country were quoted. […] Results HLA-A1 and the number of deaths per million population (severity rate) in each country had an exponential approximation correlation with correlation coefficient R=0.4879. […] Weak HLA-A alleles with a repertoire of under 300 also had an exponential approximation correlation with the severity rate (R=0.5972), whereas there was a linear approximation with the infection rate (R=0.6808). […] The weak HLA-A/B haplotype has a stronger effect on the severity rate than the weak HLA-A alone. […] The weak HLA-A is a major factor of severity rate, whereas the weak -B alone has no correlation. […] However, the weak HLA-A/B haplotype has a stronger effect on the severity rate than the weak -A alone. |
| 33586620 | Secondly, the 3D model of selected epitopes and HLA-A29:02 were built and Molecular Docking simulation was performed. […] Upon Molecular Docking, interactions between selected epitopes and HLA-A29:02 were further validated by 50 ns Molecular Dynamics (MD) simulation. |