DrugBank ID: db03419
DrugCentral: uracil
Synonymous : None

Drug Sentece Context

Table 1. Analysis of context sentence of uracil gene in 3 abstracts.

pmid sentence
32596474 We identify nucleotide changes that may be signatures of RNA editing: adenosine-to-inosine changes from ADAR deaminases and cytosine-to-uracil changes from APOBEC deaminases.
32797103 These enzymes are cytidine deaminases which transform cytosine into uracil.
33072018 A strong bias in nucleotide usage in fourfold degenerate sites toward uracil residues is seen in ORF1ab of all the studied coronaviruses: both in the ORF1a and in the ORF1b translated thanks to the programmed ribosomal frameshifting that has an efficiency of 14 - 45% in different species.
33082451 We found that there is a bias to the mutations occurring in SARS-CoV-2 variants, with disproportionate mutation to uracil (U). […] For the C-to-U mutations, the context of the upstream uracil and downstream guanine from mutated position was found to be most prevalent.
33125064 As a consequence, accidental replication errors tend to replace cytosine by uracil in the genome, unless recombination events allow the sequence to return to its ancestral sequences.
33407800 In addition, the second T in “CTG” in the DNA or uracil (U) in “CUG” in the RNA sequences from Iran can be mutated to another C by a missense mutation resulting from thymine DNA glycosylase (TDG) of human and base excision repair mechanism to produce “CCG” encoding for proline, which consequently may increase the affinity of the RNA binding domain of N protein to viral RNA and improve the transcription rate, pathogenicity, evasion from human immunity system, spreading in the human body, and risk of human-to-human transmission rate of SARS-CoV-2.
33564093 Our findings provide new insights for the development of uracil scaffold-based drugs.