DrugBank ID: db00675
Synonymous :(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine | (z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylamine | 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene | 1-para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene | tamoxifen | tamoxifène | tamoxifene | tamoxifeno | tamoxifenum | trans-tamoxifen
Drug Sentece Context
Table 1. Analysis of context sentence of tamoxifen gene in 1 abstracts.
|32663742||Tamoxifen and other anti-estrogen drugs are used in breast cancer patients who have a positive estrogen receptor (ER). […] While angiotensin II plays a key role in breast cancer etiology and causes tamoxifen resistance, angiotensin 1-7 has been reported to may reduce the spread and invasion of breast cancer. […] Tamoxifen treatment causes down-regulation, mutation, or loss in estrogen receptors. […] In the long-term use of tamoxifen, its effects on estrogen receptors can be permanent. […] Tamoxifen is a P-glycoprotein inhibitor, independent of its effect on estrogen receptors. […] We think tamoxifen may increase the COVID-19 risk due to its antiestrogen and P-glycoprotein inhibitory effects.|
|33522308||The emerging picture is that some patient groups may be particularly susceptible to SARS-CoV-2 infection and may benefit from antiandrogen- or tamoxifen-based therapies.|