Drug Sentece Context
Table 1. Analysis of context sentence of squalene gene in 2 abstracts.
|32548259||The nanoparticles are made by conjugating squalene, a natural lipid, to adenosine, an endogenous immunomodulator, and then encapsulating α-tocopherol, as antioxidant.|
|32864794||To address this, alum is packed on the squalene/water interphase is packed, forming an alum-stabilized Pickering emulsion (PAPE). […] “Inheriting” from alum and squalene, PAPE demonstrates a good biosafety profile.|
|33051497||The triterpene oil squalene is an essential component of nanoemulsion vaccine adjuvants. […] Squalene has historically been harvested from shark liver oil, which is undesirable for a variety of reasons. […] In this study, we have demonstrated the use of a Synthetic Biology (yeast) production platform to generate squalene and novel triterpene oils, all of which are equally as efficacious as vaccine adjuvants based on physiochemical properties and immunomodulating activities in a mouse model. […] Injection site morphology and serum cytokine levels did not suggest any reactogenic effects of the yeast-derived squalene or novel triterpenes, suggesting their safety in adjuvant formulations. […] These results support the advantages of yeast produced triterpene oils to include completely controlled growth conditions, just-in-time and scalable production, and the capacity to produce novel triterpenes beyond squalene.|
|33436573||Mice are vaccinated with soluble RBD or CLP-displayed RBD, formulated in Squalene-Water-Emulsion.|