DrugBank ID: db00172
DrugCentral: proline
Synonymous :(-)-2-pyrrolidinecarboxylic acid | (−)-(s)-proline | (−)-2-pyrrolidinecarboxylic acid | (−)-proline | (2s)-pyrrolidine-2-carboxylic acid | (s)-2-carboxypyrrolidine | (s)-2-pyrrolidinecarboxylic acid | (s)-pyrrolidine-2-carboxylic acid | 2-pyrrolidinecarboxylic acid | l-(−)-proline | l-alpha-pyrrolidinecarboxylic acid | l-prolin | l-proline | l-pyrrolidine-2-carboxylic acid | l-α-pyrrolidinecarboxylic acid | p | prolina | proline | prolinum

Drug Sentece Context

Table 1. Analysis of context sentence of proline gene in 5 abstracts.

pmid sentence
32083328 Position 723 in the COVID-2019 has a serine instead a glycine residue, while at aminoacidic position 1010 a proline instead an isoleucine.
32336957 The results revealed that the identified ORF1ab polyprotein belongs to a part of nonstructural protein 1 (nsp1) with the high antigenicity residues in a glycine-proline or hydrophobic amino acid rich domain.
32488835 Through this paper, we provided the list of possible chemical ligands (Meglumine, Vidarabine, Adenosine, D-Sorbitol, D-Mannitol, Sodium_gluconate, Ganciclovir and Chlorobutanol) and peptide drugs (combination of isoleucine, lysine and proline) from the databases to guide the experimental scientists and validate the molecules which can combat the virus in a shorter time.
32503918 Furthermore, both electrostatic effects and enhanced hydrophobic packing due to removal of four out of five proline residues in a short 12-residue loop lead to conformation shift toward a more tilted binding groove in the complex in comparison with the SARS-CoV complex.
32703906 Testing combinations of beneficial substitutions resulted in the identification of HexaPro, a variant with six beneficial proline substitutions exhibiting higher expression than its parental construct (by a factor of 10) as well as the ability to withstand heat stress, storage at room temperature, and three freeze-thaw cycles.
32757352 Phosphoramidates of proline hydrolyzed fast, with a half-life time as short as 2.4 h for Pro-AMP in ethylimidazole-containing buffer at 37 °C; 45-fold faster than Ala-AMP and 120-fold faster than Phe-AMP.
33037310 Further, we describe a surprising finding that the two serines at the edges of the insert SPRRAR↓SV can be efficiently phosphorylated by proline-directed and basophilic protein kinases.
33171852 The main feature of ACE inhibitory peptides is the location of the hydrophobic residue, usually Proline, at the C-terminus.
33407800 In addition, the second T in “CTG” in the DNA or uracil (U) in “CUG” in the RNA sequences from Iran can be mutated to another C by a missense mutation resulting from thymine DNA glycosylase (TDG) of human and base excision repair mechanism to produce “CCG” encoding for proline, which consequently may increase the affinity of the RNA binding domain of N protein to viral RNA and improve the transcription rate, pathogenicity, evasion from human immunity system, spreading in the human body, and risk of human-to-human transmission rate of SARS-CoV-2.