DrugBank ID: db04977
DrugCentral: plitidepsin
Synonymous :dehydrodidemnin b | plitidepsin | plitidepsina | plitidepsine | plitidepsium

Drug Sentece Context

Table 1. Analysis of context sentence of plitidepsin gene in 3 abstracts.

pmid sentence
33495306 Through the use of a drug resistant mutant, we show that the antiviral activity of plitidepsin against SARS-CoV-2 is mediated through inhibition of the known target eEF1A. […] We demonstrate the in vivo efficacy of plitidepsin treatment in two mouse models of SARS-CoV-2 infection with a reduction of viral replication in the lungs by two orders of magnitude using prophylactic treatment. […] Our results indicate that plitidepsin is a promising therapeutic candidate for COVID-19.
33558296 Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. […] Plitidepsin has shown efficacy in animal models and Phase I/II human trials. […] Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.
33578831 Initially, field-template and structure-activity atlas models were constructed to understand and explain the molecular features responsible for SARS-CoVID-2 main protease inhibitors, which revealed that Eribulin Mesylate, Plitidepsin, and Trabectedin possess similar characteristics related to SARS-CoVID-2 main protease inhibitors.