DrugBank ID: db12510
DrugCentral: ozone
Synonymous :ozono

Drug Sentece Context

Table 1. Analysis of context sentence of ozone gene in 110 abstracts.

pmid sentence
32228825 In addition, germicidal UV radiation “breaks down” the oxygen O2 which then aggregate into O3 (ozone) molecules creating the ozone layer, capable of inhibiting viral replication and improving lung respiration.
32303365 Another potential effective therapy is ozone: it has been extensively studied and used for many years and its effectiveness has been demonstrated so far in multiples studies.
32335409 In this study, concentrations of six criteria pollutants, PM10, PM2.5, CO, NO2, ozone and SO2 during March 16th to April 14th from 2017 to 2020 in 22 cities covering different regions of India were analysed.
32361428 The main goal of this work is to discuss the impact of the measures on the air quality of the city by comparing the particulate matter, carbon monoxide, nitrogen dioxide and ozone concentrations determined during the partial lockdown with values obtained in the same period of 2019 and also with the weeks prior to the virus outbreak. […] Ozone concentrations increased probably due to the decrease in nitrogen oxides level.
32380370 By contrast, an increase of approximately 30% in ozone concentrations was observed in urban areas highly influenced by vehicle traffic, probably related to nitrogen monoxide decreases.
32384798 Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. […] This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. […] It is mainly focused on ozone as a modulator of the NF-κ B/Nrf2 pathways and IL-6/IL-1β expression.
32388162 Existing experimental data showed that coronavirus survival was negatively impacted by ozone, high temperature and low humidity. […] Here, regression analysis showed that the spread of SARS-Cov-2 was reduced by increasing ambient ozone concentration level from 48.83 to 94.67 μg/m3 (p-value = 0.039) and decreasing relative humidity from 23.33 to 82.67% (p-value = 0.002) and temperature from -13.17 to 19 °C) (p-value = 0.003) observed for Chinese cities during Jan-March 2020.
32406406 Results showed that the most promising methods are those that use hydrogen peroxide vapor, ultraviolet radiation, moist heat, dry heat and ozone gas.
32413621 However, ozone did not show any reduction and increased greatly.
32416357 Particulate matter, sulfur dioxide, nitrogen oxides, ozone, carbon monoxide, volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) are among the outdoor air pollutants that are major factors in diseases, causing especially adverse respiratory effects in humans.
32437014 Ozone may exert its antiviral actions and ozone therapy has been demonstrated therapeutically usefulness in influenza and novel viruses. […] In this letter, two severe cases with COVID-19 received ozone therapy were described. […] The results showed that ozone therapy may promote recovery of clinical condition and improvement of chest CT images, shorten the duration of viral shedding and length of hospital stay.
32443202 Liquid chlorine, sodium hypochlorite, chlorine dioxide, ozone, and ultraviolet irradiation disinfection are commonly used for hospital wastewater disinfection.
32447070 The effect of lockdown due to coronavirus disease (COVID-19) pandemic on air pollution in four Southern European cities (Nice, Rome, Valencia and Turin) and Wuhan (China) was quantified, with a focus on ozone (O3).
32462858 The aim of the multicentre study promoted by Nuova FIO is to evaluate the beneficial effects of the systemic Oxygen-Ozone (O2O3) therapy in patients suffering from SARS COV-2 disease in the early phases of the disease, before worsening, up to the need of tracheal intubation. […] The study is based on the rationale on that the systemic oxygen-ozone treatment could be effective, positively influencing the disease evolution and/or being able to mitigate the onset of the cytokine storm syndrome at least partially.
32471302 We found that SARS-CoV-2 infection frequency positively correlates with particulate air pollutants, and specifically with particulate matter 2.5 (PM2.5), while ozone gas is oppositely related with the number of infected individuals.
32480061 By contrast, ozone levels increased in all studied locations. […] The increase in ozone concentrations during the social distancing measures could be attributed to the increase in NMHC/NOx ratios since atmospheric chemistry in Rio de Janeiro is under VOC-controlled conditions.
32498152 Using data on sample of N = 55 Italian province capitals, and data of infected individuals at as of April 7th, 2020, results reveal that the accelerate and vast diffusion of COVID-19 in North Italy has a high association with air pollution of cities measured with days exceeding the limits set for PM10 (particulate matter 10 μm or less in diameter) or ozone. […] In particular, hinterland cities with average high number of days exceeding the limits set for PM10 (and also having a low wind speed) have a very high number of infected people on 7th April 2020 (arithmetic mean is about 2200 infected individuals, with average polluted days greater than 80 days per year), whereas coastal cities also having days exceeding the limits set for PM10 or ozone but with high wind speed have about 944.70 average infected individuals, with about 60 average polluted days per year; moreover, cities having more than 100 days of air pollution (exceeding the limits set for PM10), they have a very high average number of infected people (about 3350 infected individuals, 7th April 2020), whereas cities having less than 100 days of air pollution per year, they have a lower average number of infected people (about 1014 individuals). […] The findings here also suggest that to minimize the impact of future epidemics similar to COVID-19, the max number of days per year that Italian provincial capitals or similar industrialized cities can exceed the limits set for PM10 or for ozone, considering their meteorological conditions, is about 48 days.
32517125 In this study, we have focused on ozone and PM2.5, two major air pollutants in New York City, which were previously found to be associated with respiratory viral infections. […] The aim of our regression modeling was to explore the associations among ozone, PM2.5, daily meteorological variables (wind speed, temperature, relative humidity, absolute humidity, cloud percentages, and precipitation levels), and COVID-19 confirmed new cases and new deaths in Queens county, New York during March and April 2020. […] The results from these analyses showed that daily average temperature, daily maximum eight-hour ozone concentration, average relative humidity, and cloud percentages were significantly and positively associated with new confirmed cases related to COVID-19; none of these variables showed significant associations with new deaths related to COVID-19. […] The findings indicate that short-term exposures to ozone and other meteorological factors can influence COVID-19 transmission and initiation of the disease, but disease aggravation and mortality depend on other factors.
32545714 Herein we propose a plausible amplification mechanism in immune defense: ozone-depleting-like halogen cyclic reactions enhancing RHS effects are responsible for all the mentioned physiological functions, which are activated by H2O2 and deactivated by NO signaling molecule. […] Our results show that the reaction cycles can be repeated thousands of times and amplify the RHS pathogen-killing (defense) effects by 100,000 fold in phagocytosis, resembling the cyclic ozone-depleting reactions in the stratosphere.
32554754 Also, because of non-linear production chemistry and titration of ozone in winter, reduced nitrogen oxides resulted in ozone enhancement in urban areas, further increasing the atmospheric oxidizing capacity and facilitating secondary aerosol formation.
32559534 For January-April 2020 period, time series of daily average inhalable gaseous pollutants ozone (O3) and nitrogen dioxide (NO2), together climate variables (air temperature, relative humidity, wind speed, precipitation rate, atmospheric pressure field and Planetary Boundary Layer) were analyzed. […] Exhibited positive correlations of ambient ozone levels and negative correlations of NO2 with the increased rates of COVID-19 infections (Total number, Daily New positive and Total Deaths cases), can be attributed to airborne bioaerosols distribution. […] Also, in spite of collected data for cold season (winter-early spring) period, when usually ozone levels have lower values than in summer, the findings of this study support possibility as O3 can acts as a COVID-19 virus incubator.
32567938 Ozone therapy could be of great help in the control of the progression of the asymptomatic carious lesions, especially during the Phase 2 of reopening, when we should to minimise the use of rotating instruments producing aerosols.
32593893 This study shows that the lockdown effect on atmospheric composition, in particular through massive traffic reductions, has been important for several short-lived atmospheric trace species, with a large reduction in NO2 concentrations, a lower reduction in Particulate Matter (PM) concentrations and a mitigated effect on ozone concentrations due to non-linear chemical effects.
32629257 Hourly air pollution observations were obtained for fine particulate matter, nitrogen dioxide, nitrogen oxides and ozone from the Ontario air monitoring network for 2020 and the previous five years. […] Ozone concentrations at 12 of the 32 monitors were lower than any of the previous five-years; however, four locations were above average. […] Average ozone concentrations were 1 ppb lower during the SOE, but this ranged at individual monitors from 1.5 ppb above to 4.2 ppb below long-term conditions. […] Overall, both nitrogen dioxide and nitrogen oxides demonstrated a reduction across Ontario in response to the COVID-19 SOE, ozone concentrations suggested a possible reduction, and fine particulate matter has not varied from historic concentrations.
32634686 Nitrogen dioxide (NO2) showed the largest decrease of approximately 53.3%, and ozone (O3) increased by 116.6%.
32655532 Specifically, we focused on the effects of alcohols, povidone iodine, quaternary ammonium compounds, hydrogen peroxide, sodium hypochlorite (NaOCl), peroxyacetic acid (PAA), chlorine dioxide, ozone, ultraviolet light, metals, and plant-based antimicrobials.
32674410 The study investigated the levels of four air pollutants-Carbon monoxide (CO), Ozone (O3), Fine Particulate (PM2.5) and Nitrogen dioxide (NO2)-during the month of March 2020, compared to 2015-2019, in the urban air of these metropolitan areas, controlling for meteorological variables. […] In contrast, tropospheric ozone levels increased, except in Los Angeles.
32679925 The variables retained by the models were identical for nitrogen dioxide (NO2), particulate matter (PM10), PM2.5, but not for ozone (O3) Air pollution data from 2019 was used for validation purposes.
32718835 Air pollutants such as sulfur oxides, nitrogen oxides, carbon monoxide and dioxide, particulate matter (PM), ozone and volatile organic compounds (VOCs) are commonly found at high levels in big cities and/or in the vicinity of different chemical industries.
32723816 After accounting for the effects of meteorological variability, we find declines in the population-weighted concentration of ground-level nitrogen dioxide (NO2: 60% with 95% CI 48 to 72%), and fine particulate matter (PM2.5: 31%; 95% CI: 17 to 45%), with marginal increases in ozone (O3: 4%; 95% CI: -2 to 10%) in 34 countries during lockdown dates up until 15 May. […] Except for ozone, satellite measurements of the troposphere indicate much smaller reductions, highlighting the spatial variability of pollutant anomalies attributable to complex NOx chemistry and long-distance transport of fine particulate matter with a diameter less than 2.5 µm (PM2.5).
32731074 Significant reductions of particulate matter (PM2.5 and PM10) only occurred in the Northeast and California/Nevada metropolises where NO2 declined the most, while the changes in ozone (O3) were mixed and relatively minor.
32738690 We study the variation of tropospheric NO2 vertical column densities (TropNO2VCDs) over East China during the 2005-2020 lunar new year (LNY) holiday seasons to understand factors on the reduction of tropospheric NO2 during the outbreak of COVID-19 in East China using Ozone Monitoring Instrument (OMI) and TROPOspheric Monitoring Instrument (TROPOMI) observations.
32748790 The monikers “coronavirus ozone,” “coronavirus laboratory,” “coronavirus 5G,” “coronavirus conspiracy,” and “coronavirus bill gates” were widely circulated on the internet.
32771791 The purpose of this study is to understand the effect of lockdown on air pollutants and to analyze pre-monsoon (April and May) cloud-to-ground and inter-cloud lightning activity in relation to air pollutants i.e. suspended Particulate matter (PM10), Nitrogen dioxides (NO2) Sulfur dioxide (SO2), Ozone (O3) and Aerosol concentration (AC) in a polluted tropical urban megacities like Kolkata.
32781318 This paper analyses the impact of the control measures during the COVID-19 lockdown in Europe (15 March-30 April 2020) on 1-h daily maximum nitrogen dioxide (NO2) and maximum daily 8-h running average ozone (MDA8 O3) observations obtained from the European Environment Agency’s air quality database (AirBase).
32795898 This study evaluated the potential efficacy of a novel approach to treat COVID-19 patients, using an oxygen-ozone (O2-O3) mixture, via a process called Oxygen-Ozone- Immunoceutical Therapy.
32804917 Ozone therapy consists of administration of a mixture of oxygen and ozone (a molecule consisting of 3 oxygen atoms). […] CASE REPORT We report rapidly improved hypoxia with associated decreases in inflammatory markers and D-dimer immediately after 1-4 sessions of oxygen-ozone (O₂-O₃) therapy in 3 patients with COVID-19 pneumonia who presented with respiratory failure.
32806422 Pollution data included three types of air emission concentrations (particulate matter<2.5 μm (PM2.5), ozone and diesel particulate matter (DPM)), and four pollution source variables (proximity to traffic, National Priority List sites, Risk Management Plan (RMP) sites, and hazardous waste treatment, storage and disposal facilities (TSDFs)).
32834964 Our analysis has considered March and April 2020, for air quality measurement and infections in Lima, the data collected on 6 meteorological stations with CO (carbon monoxide), NO2 (nitrogen oxide), O3 (ozone), SO2 (sulfur dioxide), PM10 and PM2.5 (particle matter with diameter aerodynamic less than 2.5 and 10 m respectively).
32836516 At the same time, the mean ozone concentration has increased by a factor 1.5-2. […] In urban area of Wuhan, where drastic measures were adopted to limit the spread of the coronavirus, similar changes in the concentrations of PM2.5, NO2 and ozone are found.
32837285 In this study, the authors investigated the changes of AQI for 2.5 µm particulate matter (PM2.5), a primary air pollutant, as well as ozone, a secondary air pollutant, in Turkey during December 2019, April 2020, and May 2020. […] However, the ozone index increased from 16.8 to 28.8 by the end of April. […] The increase in ozone is attributed to the reduction of PM levels, which increased sunlight penetration.
32837481 Here we studied changes in particulate matter (PM2.5, PM10), carbon monoxide (CO), NO2, sulfur dioxide (SO2) and ozone (O3) at 10 urban sites in Hangzhou, a city of 7.03 million inhabitants, and at 1 rural site, before city lockdown, January 1-23, during city lockdown, January 24-February 15, and during resumption, February 16-28, in 2020. […] Overall, we observed not only the expected reduction in some atmospheric pollutants (PM, SO2, CO, NO2), but also unexpected increases in SO2 in the rural areas and of ozone (O3) in both urban and rural areas, the latter being paradoxically due to the reduction in nitrogen oxide levels.
32837616 In order to understand the variations in the level of pollutant accumulation amid the lockdown period, a trend analysis is performed for 24 h daily average data for five pollutants (PM2.5, PM10, NO2, SO2, and ozone).
32838159 Of these, there are only three that consider ozone therapy (major auto hemotherapy) as an alternative option. […] There is no study that evaluates rectal ozone insufflation, despite being a safe, cheap, risk-free technique. […] That technique is a systemic route of ozone administration (95-96%) and that could be extrapolated to the use of SARS-CoV-2, given the excellent results observed in the management of Ebola. […] Ozone has four proven biological properties that could allow its use as an alternative therapy in the different phases of SARS-CoV-2 infection. […] Ozone could inactivate the virus by direct (O3) or indirect oxidation (ROS and LOPs) and could stimulate the cellular and humoral immune systems, being useful in the early COVID-19 infection phase (stages 1 and 2a). […] Ozone improves gas exchange, reduces inflammation, and modulates the antioxidant system, so it would be useful in the hyper inflammation or “cytokine storm” phase, and in the hypoxemia and/or multi-organ failure phase (stage 2b and stage 3). […] Given the current pandemic, it is urgent to carry out an experimental study that confirms or rules out the biological properties of ozone and thus allows it to be an alternative or compassionate therapy for the effective management of SARS-Cov-2 infection. […] The Ethical Committee at our Hospital has authorized the use of this technique for compassionate management of SARS-CoV-2 infection, considering the four biological Ozone properties exposed previously.
32838181 The aim of this study is to evaluate the effectiveness of rectal ozone (O3) in COVID-19 patients with severe pneumonia admitted at Hospital Universitario Santa Cristina, Madrid. […] In a before-and-after study, four patients admitted with severe bilateral pneumonia due to COVID-19 were treated with rectal ozone and confirmed with (+) RT-PCR for SARS-CoV-2 and evaluated afterwards. […] The treatment protocol consisted of 5 sessions (1 session/day) of intra-rectal ozone, applied in a volume of 100 mL and a concentration of 35 μg/mL. […] Rectal ozone decreases O2 supply and improves O2 saturation, decreases inflammation biomarkers, and improves Taylor’s radiological grade in patients with severe COVID-19 pneumonia. […] Rectal ozone is a safe, effective, cheap, and simple alternative capable of acting on the SARS-CoV-2 virus, and it is presented as an adjunctive therapeutic option to consider in the management of severe bilateral COVID-19 pneumonia.
32863711 The COVID-19 lockdown presented a peculiar opportunity to study a shift in the photochemical regime of ozone production in Quito (Ecuador) before and after mobility restrictions. […] Primary precursors such as NO and CO dropped dramatically as early as 13 March 2020, due to school closures, but ambient ozone did not change. […] In this work we use a chemical box model in order to estimate regimes of ozone production before and after the lockdown. […] We constrain the model with observations in Quito (ozone, NOx, CO, and meteorology) and with estimations of traffic-associated VOCs that are tightly linked to CO. […] With reduced NOx in the morning rush hour (lockdown conditions), ozone production rates at 08:30-10:30 increased from 4.2 to 17 to 9.7-23 ppbv h-1, respectively. […] To test further the observed shift in chemical regime, ozone production was recalculated with post-lockdown NOx levels, but setting VOCs to pre-lockdown conditions. […] This change tripled ozone production rates in the mid-morning and stayed higher throughout the day. […] In light of these findings, practical scenarios that present the potential for ozone accumulation in the ambient air are discussed.
32864482 Satellite-based ozone monitoring instrument sensor data were analyzed in order to investigate the variations in tropospheric NO2 concentrations.
32904471 The studied air pollutants include carbon monoxide (CO), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and inhalable particulate matter (PM10).
32919963 This study draws the link between COVID-19 and air pollution (ground ozone O3) from 29 February 2020 to 10 July 2020 in the top 10 affected States of the US.
32952739 However, we also find the ozone levels increased (∼ 10%), and the levels of sulphur dioxide more than doubled across the country.
32952740 Estimated UVB inactivation doses from sunlight in J/m2 are obtained from UVC measurements and radiative transfer calculations, weighted by a virus inactivation action spectrum, using OMI satellite atmospheric data for ozone, clouds, and aerosols.
32980021 On the other hand, due to sole mass control, there are significant changes of overall pollutant fingerprint, such as the increase of ground-level ozone concentration, which should be taken into account for altered health effects relative to the past.
32981442 We suggest that the unprecedented and unintended decrease of emissions of air pollutants during the COVID-19 lock-down in 2020 could lead to declining seasonal ozone concentrations and positive impacts on crop yields. […] The greatest ozone reductions during the growing season reached up to 12 ppb over crop growing regions in Asia and up to 6 ppb in North America and Europe for the 50% global reduction scenario. […] In Europe, ozone responses are more sensitive to emission declines in other continents, international shipping and aviation than to emissions changes within Europe. […] We demonstrate that for wheat the overall magnitude of ozone precursor emission changes could lead to yield improvements between 2% and 8%. […] The expected magnitude of ozone precursor emission reductions during the Northern Hemisphere growing season in 2020 presents an opportunity to test and improve crop models and experimentally based exposure response relationships of ozone impacts on crops, under real-world conditions.
32989376 The ozone (O3) concentration was high at Delhi because of lesser greenery as compared to UP and Haryana, which provides higher atmospheric temperature favourable for O3 formation.
32992843 Surfactant protein (SP-) A modulates the functions of alveolar macrophages (AM) and ozone (O3) exposure in the presence or absence of SP-A and reduces mouse survival in a sex-dependent manner.
33004712 Ozone therapy consists in the administration of a mixture of ozone and oxygen, called medical ozone, which has been used for over a century as an unconventional medicine practice for several diseases. […] Medical ozone rationale in COVID-19 is the possibility of contrasting endothelial dysfunction, modulating the immune response and acting as a virustatic agent. […] Thus, medical ozone could help to decrease lung inflammation, slow down viral growth, regulate lung circulation and oxygenation and prevent microvascular thrombosis. […] Ozone-therapy could be considered a feasible, cost-effective and easy to administer adjuvant therapy while waiting for the synthesis of a therapy or the development of the vaccine.
33016156 To help investigate the relationship between inflammatory and other symptoms of coronavirus and the protein-protein interactions (PPI) that occur between viral proteins and protein molecules of the host cell, I propose that the electrostatic discharge (ESD) exists including corona discharge to lead to ozone gas.
33021366 No statistically significant effect of traffic ban was found at Fortnight, Weekly or Sunday analyses for daily mean concentrations of benzene, carbon monoxide, nitric oxide, nitrogen dioxide, ozone, sulfur dioxide, particulate matter (PM) <2.5 μm or PM <10 μm (all p>0.05). […] However, minimum daily concentrations showed a significant reduction of ozone during the ban in comparison to the week preceding it (p=0.034), nitric oxide during the ban in comparison to the 3 days preceding it (p=0.046), and an increase in benzene during the ban in comparison to the Sunday before (p=0.039).
33022781 We have focused on the potential effect of exposure to nitrogen dioxide (NO2), ozone (O3), and particulate matter (PM) since there are studies investigating how exposure to these pollutants affects the life cycle of other viruses.
33040289 The present study aims to determine the impact of COVID-19 pandemic confinement on air quality among populous sites of four major metropolitan cities in India (Delhi, Mumbai, Kolkata, and Chennai) from January 1, 2020 to May 31, 2020 by analyzing particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), ammonia (NH3), sulfur dioxide (SO2), carbon monoxide (CO), and ozone levels.
33040775 From the experimental work, it has been observed that the pollutants Ozone and Toluene have increased during the lockdown period. […] It has also been deduced that the pollutants that may impact the mortalities due to COVID-19 are Ozone, NH3, NO2, and PM10. […] However, there is a need to impose measures to control Ozone pollution as there has been a significant increase in its concentration and it also impacts the COVID-19 mortality rate.
33045513 We found that de-trended particulate matter concentrations had been influenced by interregional pollution episodes, and de-trended ozone concentrations had increased across most sites, by up to 15%, such that total Ox levels were roughly preserved. […] 0-D chemical box model simulations showed the observed increases in ozone concentrations during lockdown under the hydrocarbon-limited ozone production regime, where total NOx decreased proportionally greater than total non-methane hydrocarbons, which led to an increase in total hydroxyl, peroxy and organic peroxy radicals.
33063773 Due to its toxicity, ozone is not the first-choice method for air decontamination of enclosed clinical settings.
33069147 In contrast, ozone levels increased by about 2% over Cairo and Alexandria governorates.
33071605 In the present work, Life Cycle Assessment of PPE kits has been performed using GaBi version 8.7 under two disposal scenarios, namely landfill and incineration (both centralized and decentralized) for six environmental impact categories covering overall impacts on both terrestrial and marine ecosystems, which includes Global Warming Potential (GWP), Human Toxicity Potential (HTP), Eutrophication Potential (EP), Acidification Potential (AP), Freshwater Aquatic Ecotoxicity Potential (FAETP) and Photochemical Ozone Depletion Potential (POCP).
33111980 To evaluate the adjuvant use of systemic oxygen-ozone administration in the early control of disease progression in patients with COVID-19 pneumonia. […] Patients were randomly divided into ozone-autohemotherapy group (14) and control group (14). […] The procedure consisted in a daily double-treatment with systemic Oxygen-ozone administration for 7 days. […] Thirty-day mortality was 8.3% for ozone group and 10% for controls. […] Ozone therapy did not significantly influence inflammation markers, hematology profile, and lymphocyte subpopulations of patients treated. […] Ozone therapy had an impact on the need for the ventilatory support, although did not reach statistical significance. […] Finally, no adverse events related to the use of ozone-autohemotherapy were reported. […] Preliminary results, although not showing statistically significant benefits of ozone on COVID-19, did not report any toxicity.
33115670 The main objective of this narrative review is to describe the available evidence on the possible antiviral activity of ozone in patients with COVID-19 and its therapeutic applicability through hospital protocols. […] Amongst different possible therapies for SARS-CoV-2 pneumonia, ozone therapy seems to have an immunological role because of the modulation of cytokines and interferons, including the induction of gamma interferon. […] Some data suggest the possible role of ozone therapy in SARS, either as a monotherapy or, more realistically, as an adjunct to standard treatment regimens; therefore, there is increasing interest in the role of ozone therapy in COVID-19 treatment The PubMed and Scopus databases and the Italian Scientific Society of Oxygen Ozone Therapy website were used to identify articles focused on ozone therapy. […] Of 280 articles found on ozone therapy, 13 were selected and narratively reviewed. […] Ozone exerts antiviral activity through the inhibition of viral replication and direct inactivation of viruses. […] Ozone is an antiviral drug enhancer and is not an alternative to antiviral drugs. […] Combined treatment with involving ozone and antivirals demonstrated a reduction in inflammation and lung damage. […] The routes of ozone administration are direct intravenous, major autohaemotherapy and extravascular blood oxygenation-ozonation. […] Systemic ozone therapy seems useful in controlling inflammation, stimulating immunity and as antiviral activity and providing protection from acute coronary syndromes and ischaemia reperfusion damage, thus suggesting a new methodology of immune therapy. […] Systemic ozone therapy in combination with antivirals in COVID-19-positive patients may be justified, helpful and synergic.
33131530 We found that: (i) Interactome-based infection pathways differ from the other three omics-based profiles. (ii) Viral process, mRNA splicing, cytokine and interferon signaling, and ubiquitin mediated proteolysis are important pathways in SARS-CoV-2 infection. (iii) SARS-CoV-2 infection also shares pathways with Influenza A, Epstein-Barr virus, HTLV-I, Measles, and Hepatitis virus. (iv) Further, bacterial, parasitic, and protozoan infection pathways such as Tuberculosis, Malaria, and Leishmaniasis are also shared by this virus. (v) A total of 50 candidate drugs, including the prophylaxis agents and pathway specific inhibitors are identified against COVID-19. (vi) Betamethasone, Estrogen, Simvastatin, Hydrocortisone, Tositumomab, Cyclosporin A etc. are among the important drugs. (vii) Ozone, Nitric oxide, plasma components, and photosensitizer drugs are also identified as possible therapeutic candidates. (viii) Curcumin, Retinoic acids, Vitamin D, Arsenic, Copper, and Zinc may be the candidate prophylaxis agents.
33145359 A total of 86 papers were retrieved by the electronic research. vapor, (3) ultraviolet C light, (4) pulsed xenon, and (5) gaseous ozone.
33150218 The new SARS-CoV-2/COVID-19 emergency has imposed new disinfection and sanitation measures of work environments also to beauty and health professional workers and in this context ozone shows growing interest. […] Ozone has proven to be highly effective in killing bacteria, fungi, and molds and inactivating viruses both on the surfaces and suspended in the air. […] Ozone is proven to be effective also for the inactivation of the SARS virus, while for the novel SARS-CoV-2 it is supposed that it be equally effective but specific studies are needed.
33168247 Population density used as a background variable to increase understanding of the observed differences allowed us to propose that reductions in NOx were so drastic that ozone formation moved rapidly from a VOC sensitive region towards a NOx sensitive region.
33173248 Changes in human exposure are associated with about 2,100 more ozone-related and at least 60,000 fewer PM2.5-related morbidity incidences, primarily from asthma cases, thereby augmenting efforts to reduce hospital admissions and alleviate negative impacts from potential delayed treatments.
33176412 Despite various opinions and healthy controversy on Ozone Therapy (OT), the practices of this therapy have increased worldwide. […] On the other hand, there is a net dissociation of the scientific resonance concerning systemic oxygen/ozone treatments. […] It is our intention to discuss in logical terms the numerous papers that commendably reported adverse reactions attributable to OT, focusing our attention mainly to the techniques of administration and not to the simple contact of ozone with biological material. […] Commonly, the molecule of ozone itself is not responsible of severe reactions at the therapeutic modalities.
33192209 Ultrasound technology and ozone treatment are suitable to preserve heat sensitive foods.
33230863 Treatment with 0.1 and 0.05 ppm ozone gas for 10 and 20 hr, respectively, decreased SARS-CoV-2 infectivity by about 95%. […] Treatment with 1 and 2 mg/L ozone water for 10 s reduced SARS-CoV-2 infectivity by about 2 and 3 logs, respectively. […] Our results suggest that low-dose ozone, in the form of gas and water, is effective against SARS-CoV-2.
33231674 In an analysis including the provinces of Lombardia and neighboring regions, SARS-CoV-2 cases and mortality increased when the distance from Lodi reduced below 92 km and 140 km, respectively, and such relationships were amplified by ozone (O3) pollution.
33242027 Since ozone has a proven anti-viral action, we present a project on the use of ozonized water in the water circuit of the dental armchair, in order to lower the viral load during dental practice in dental clinics and hospitals.
33243576 During the lockdown the ozone patterns were different for each studied location, depending on the VOCs-NOx ratios, with concentration changes close to those expected from the historical series in each site and not statistically attributable to the health crisis effects.
33245297 Using publicly accessible data collected by the United States Census Bureau, Environmental Protection Agency, and other agencies, county-level mortality rates were regressed on concentration values of ground-level ozone, nitrogen dioxide, carbon monoxide, and sulfur dioxide. […] Regression analysis showed that ground-level ozone is positively correlated with county-level mortality rates regardless of whether confounders are controlled for. […] High ground-level ozone and nitrogen dioxide concentrations contribute to a greater COVID-19 mortality rate.
33251108 However, the removal of several recalcitrant organic pollutants are less responsive to those processes and demands the application of tertiary treatments, such as adsorption, ozone treatment, UV treatment, etc.
33254633 The higher levels of ozone at both PD and DSL on CP might be due to the weak nitrogen monoxide titration, low relative humidity and high visibility compared with NCP.
33283072 Ozone production was evaluated after extended bulb run time. . […] No ozone production was noted in the UVC system. should be significantly increased to account for geometry of FFR and lateral dose fall off.
33287216 Meanwhile, ozone concentration in the downwind suburban was as low as the central city and soared in few stations amid post-lockdown, simultaneous the correlation between ozone and other pollutants converted from negative to positive. […] The trajectory indicated that the pollution sources during the lockdown and pre-lockdown were basically Southern Russia, Inner Mongolia, and the three provinces of Northeast China, the pollution from the Bohai Sea provoked ozone pollutants in Shenyang to rebound briskly amid post-lockdown, the pollution of neighboring countries and areas would have a stronger impact on air quality under the effect of lockdown.
33287249 Ozone is a powerful oxidant agent. […] The objectives of this study were to examine the effects of ozone treatment on PPE contaminated with SARS-CoV-2, and to explore whether relative humidity could modify those effects. […] PPE contaminated by heat-inactivated SARS-CoV-2 were treated with different ozone concentrations, exposure times, and relative humidity conditions. […] Oxidative stress induced by ozone exposure eliminated heat-inactivated SARS-CoV-2 in different PPE components under appropriate exposure times, ozone concentrations, and relative humidity conditions.
33291673 and ozone concentrations with COVID-19 infected cases.
33297239 Lockdown had a healing effect on ozone; significant increase in its concentration was observed.
33310665 Depending on the bed the patient was admitted, the treatment was ozone autohemotherapy or standard treatment. […] Each treatment involved administration of 200 mL autologous whole blood enriched with 200 mL of oxygen-ozone mixture with a 40 μg/mL ozone concentration.
33344687 These viruses, being RNA viruses, are found to be susceptible to ozone. […] Ozone being an unstable molecule can breakup into its split products namely reactive oxygen species and ozonides creating a toxic environment for these viruses. […] Ozone mainly prevents the membrane fusion with the host cell, thus interfering with their replication. […] In this context, this article provides insights from recent clinical and research studies on the problems and possibilities in employing the ozone to combat the coronaviruses.
33389580 Maximum antiviral activity of ozone is achieved at high humidity, while the same ozone concentrations under low RH could result inefficient. […] At these ozone levels, safety protocols must be strictly followed.
33391845 Environmental factors influencing were analyzed and indicated that the SARS-CoV-2 transportation in aerosol was dependent on temperature, air humidity, ventilation rate and inactivating chemicals (ozone) content.
33398753 or ozone, cities located in hinterland zones (i.e. away from the coast), cities having a low average speed of wind and cities with a lower average temperature.
33399524 This study proves how two widespread disinfection systems, short-wavelength ultraviolet light (UV-C) and ozone (O3), are active in vitro on different commonly used materials. […] The development of devices equipped with UV-C, or ozone generators, may prevent the virus from spreading in public places.
33412807 Therefore, there is a need for a homogeneous and applicable exposure assessment tool throughout the country.Experiences of high spatio-temporal resolution models for Italian territory already exist for PM estimation, using space-time predictors, satellite data, air quality monitoring data.This work completes the availability of these estimations for the most recent years (2016-2019) and is also applied to nitrogen oxides and ozone. […] The spatial resolution is 1x1 km.The model confirms its capability of capturing most of PM variability (R2=0.78 and 0.74 for PM10 e PM2.5, respectively), and provides reliable estimates also for ozone (R2=0.76); for NO2 the model performance is lower (R2=0.57).
33417905 The results reiterate the significance of uniformly adhering to air pollution mitigation strategies, especially related to ground-level ozone.
33421928 This study is aimed at evaluating the safety and efficacy of ozone therapy (OT), as an adjuvant to the standard of care (SOC).
33456479 In this study, the effects of four air pollutants (carbon monoxide, nitrogen dioxide, ozone, and sulfur dioxide) were assessed from February 19 to March 22, 2020 to explore how they can affect COVID-19 contagion in Iran. […] Carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone had both considerable negative and positive correlations with the density of confirmed COVID-19 cases, although sulfur dioxide was correlated more negatively than positively.
33458449 It is worth noting that along with these positive outcomes, secondary pollutants such as ozone, however, remained unchanged or even increased significantly.
33462542 For instance, the use of ozone gas as a safe and potent disinfectant against SARS-CoV-2 virus is of particular interest. […] Here we tested the use of pseudoviruses as a model for evaluating ozone disinfection of the coronavirus at ozone concentrations of 30, 100, and 1000 ppmv. […] Results show that ozone disinfection rate of pseudoviruses was similar to that of coronavirus 229E (HuCoV-229E) at short contact times, below 30 min. […] Viral infection decreased by 95% following ozone exposure for 20 min at 1000 ppmv, 30 min at 100 ppmv and about 40 min at 30 ppmv. […] This findings mean that ozone is a powerful disinfectant toward the enveloped pseudovirus even at low ozone exposure. […] Infected surfaces made of aluminum alloy, for example, were better disinfected with ozone as compared to brass, copper, and nickel surfaces. […] Lastly, we demonstrate the advantage of ozone over liquid disinfectants by showing similar viral disinfection on top, side, bottom, and interior surfaces. […] Overall, our study demonstrates the potential use of ozone gas disinfection to combat the COVID-19 outbreak.
33476982 Although inhaling ozone (O3) gas has been shown to be toxic to the lungs, recent evidence suggests that its administration via appropriate routes and at small doses can paradoxically induce an adaptive reaction capable of decreasing the endogenous oxidative stress. […] Ozone therapy is recommended to counter the disruptive effects of severe COVID-19 on lung tissues, especially if administered in early stages of the disease, thereby preventing the progression to ARDS.
33477576 Our results indicate that maximum temperature, minimum temperature, humidity, the percentage of cloud coverage, and the columnar density of total atmospheric ozone have a strong association with the COVID-19 pandemic in many states. […] In particular, the maximum temperature, minimum temperature, and the columnar density of total atmospheric ozone demonstrate statistically significant associations with the tendency of COVID-19 spreading in almost all states.
33488840 remain almost stable and oxidation of these species leads to the formation of ozone and organic aerosol, which also explains the increase in PM during the lockdown.
33516798 Here we report on an investigation into the use of gaseous ozone as a potentially effective sanitizing method against the new coronavirus.
33521243 The mitigating role was also observed for ozone/solar radiation and temperature/long-wave radiation in the UAE and Switzerland, respectively.
33527848 ozone generation are complementary techniques for an effective virucidal treatment of the air.
33529325 In an analysis including the provinces of Lombardia and neighboring regions, SARS-CoV-2 cases and mortality increased when the distance from Lodi reduced below 92 and 140 km, respectively, and such relationships were amplified by ozone (O3) pollution.
33534912 The recent development of even shorter-wavelength UV-C lamps, such as the Krypton-Chloride, 222-nm lamp, has led to greater concerns about the UV-C generation of ozone. […] It is well known that wavelengths below 240 nm more readily generate ozone. […] However, there is a great misunderstanding with regard to the actual generation and dissipation of ozone molecules by UV-C lamps. […] An overview of the ozone generation of various UVC light sources is presented to give users a better understanding of risk and how to assure control of ozone when employing UV-C lamps.
33538312 Many of the anthropogenic contributors to air pollution are also sources of greenhouse gases including CO2 and other short-lived climate pollutants, such as Ozone and black carbon, which greatly contribute to the climate change phenomenon and its adverse effects on human health.
33553707 The data obtained from this study advances the fundamental understanding of ozone chemistry that may lead to improved ozone parameterization in chemical transport models and better planning of ozone risk management strategies for any global mega cities.
33561448 Among the pollutants, ozone, and among the meteorological variables, temperature, explained the highest variability, up to 34% and 30% respectively, for COVID-19 confirmed cases and deaths.
33573007 Air pollution data were collected over the Lombardy region, nominally, sulphur dioxide, ammonia, nitrogen dioxide, nitrogen monoxide, carbon monoxide, ozone, and suspended particulate matter measuring less than 10 μm (PM10) and less than 2.5 μm (PM2.5). […] The analysis evidenced a positive correlation between spatial distribution of COVID-19 infection cases with high concentrations of suspended particulate matter and a negative relationship with ozone.