DrugBank ID: db00368
DrugCentral: norepinephrine
Synonymous :(−)-arterenol | (−)-noradrenaline | (−)-norepinephrine | (r)-(−)-norepinephrine | (r)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol | (r)-noradrenaline | (r)-norepinephrine | 4-[(1r)-2-amino-1-hydroxyethyl]-1,2-benzenediol | arterenol | l-noradrenaline | l-norepinephrine | nor-adrenaline | noradrenaline | norepinefrina | norépinéphrine | norepinephrine | norepinephrinum

Drug Sentece Context

Table 1. Analysis of context sentence of norepinephrine gene in 19 abstracts.

pmid sentence
32488505 All children but one needed an inotropic/vasoactive drug support (epinephrine, n = 12; milrinone, n = 10; dobutamine, n = 6, norepinephrine, n = 4) and 8 were intubated.
32495913 At admission, the patient was hemodynamically unstable requiring circulatory support with liquids and norepinephrine; laboratory tests showed disseminated intravascular coagulation (DIC).
32586396 All patients aged 18- 80 with positive polymerase chain reaction (PCR) test for SARS-CoV-2, a C-reactive protein (CRP) ≥ 100 mg/l, a Procalcitonin (PCT) < 2 ng/l, and suspected cytokine storm defined via a vasoplegic shock (Norepinephrine > 0.2 μg/min/kg to achieve a Mean Arterial Pressure ≥ 65mmHg).
32680896 Undifferentiated shock may be treated initially with norepinephrine to optimize perfusion while additional evaluation is performed to categorize the shock pathophysiology.
32838394 Forty-eight (42%) patients were hypotensive and required norepinephrine immediately post-intubation.
32957066 Most often reported cortisol represents the currently best evaluated stress marker, while norepinephrine (noradrenaline) or its metabolite 3-methoxy-4-hydroxyphenylglycol is also a quite commonly considered stress marker.
33031192 The hemodynamic response to angiotensin II was estimated by recording the mean arterial pressure, norepinephrine equivalent dose (NED) and urine output. […] Over the initial 6 hours, the average the norepinephrine equivalent dose decreased by 30.4% (from 64.6 mcg/min to 44 mcg/min) without a significant change in the mean arterial pressure (0.7% decrease). […] Six patients experienced at least a 25% reduction in norepinephrine equivalent dose by 6 hours, and two experienced at least a 50% reduction.
33063034 All patients were admitted to the ICU with respiratory failure and were receiving norepinephrine for distributive shock.
33105136 In 84 (65%) PIRRT procedures, there was a median increase in norepinephrine dose of +0.031 mcg/kg/min during PIRRT (IQR 0.00 to +0.07).
33221013 Antidepressants are drugs with a direct action on the brain’s biochemistry through their interaction with the neurotransmitters, such as dopamine, norepinephrine, and serotonin.
33239507 Norepinephrine was titrated to restore mean arterial pressure to baseline values (~80 mm Hg). […] The norepinephrine dose was decreased, to zero in four of five sheep, whereas mean arterial pressure increased (to 83 ± 2 mm Hg).
33251008 On eighth day, his condition deteriorated with blood pressure 80/40 mmHg with norepinephrine support, pulse 109x/minute, and SpO2 72% with ventilator.
33308005 Initial treatment consisted of sodium bicarbonate, lipid emulsion, diazepam and norepinephrine.
  1. The dosage of norepinephrine increased from 0.15 μg/kg/min (-1 h) to 0.40 μg/kg/min (24 h).
33350378 Where available and not prohibited by cost, we recommend using norepinephrine, given its safety profile.
33372818 She remained hypotensive, despite high-dose epinephrine and norepinephrine infusions as well as stress-dose hydrocortisone.
33409050 On the same day, his hypoxia worsened with an increase in pulmonary infiltrates, so we stopped intravenous fluids and initiated norepinephrine for 24 hours.
33421802 IQVIA Total Patient Tracker data were used to calculate U.S. monthly numbers of unique patients dispensed buprenorphine, extended-release (ER) intramuscular naltrexone, naloxone, selective serotonin or serotonin-norepinephrine reuptake inhibitors, benzodiazepines, and for comparison, HMG-CoA reductase inhibitors (statins) and angiotensin receptor blockers (ARBs) between January 2019-May 2020.
33459706 Another insufficiently considered aspect of cerebral proinflammatory cytokines is the fitness of the endogenous cerebral anti-TNF system provided by norepinephrine (NE), generated and distributed throughout the brain from the locus coeruleus (LC).