DrugBank ID: db01115
DrugCentral: nifedipine
Synonymous :4-(2’-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredimethylester | nifedipine | nifedipino | nifedipinum

Drug Sentece Context

Table 1. Analysis of context sentence of nifedipine gene in 15 abstracts.

pmid sentence
32226695 Other therapeutics to consider that are also directed towards decreased pulmonary pressure include Nifedipine and Phosphodiesterase inhibitors. […] Acetazolamide, Nifedipine and Phosphodiesterase inhibitors may be potential countermeasures.
32411566 With 65 patients left, 24 were found to have been administered either amlodipine or nifedipine (CCB group) and 41 were not (No-CCB group). […] Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. […] Including either nifedipine or amlodipine in medication regimens for elderly patients with hypertension hospitalized for COVID-19 may be considered.
33269470 Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. […] Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the combination of ritonavir and nifedipine can potentially cause drug-drug interactions. […] This study provides guidance on nifedipine treatment during and after coadministration with ritonavir-containing regimens, using a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) analysis. […] The PBPK/PD models for 3 formations of nifedipine were developed based on the Simcyp nifedipine model and the models were verified using published data. […] The effects of ritonavir on nifedipine exposure and systolic blood pressure (SBP) were assessed for instant-release, sustained-release and controlled-release formulations in patients. […] Various nifedipine regimens were investigated when coadministered with or without ritonavir. of nifedipine 17.92-48.85-fold and the AUC 63.30-84.01-fold at steady state and decreased the SBP by >40 mmHg. […] Thus, the combination of nifedipine and ritonavir could lead to severe hypotension. […] Ritonavir significantly affects the pharmacokinetics and antihypertensive effect of nifedipine. […] It is not recommended for patients to take nifedipine- and ritonavir-containing regimens simultaneously.