DrugBank ID: db00704
DrugCentral: naltrexone
Synonymous :17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one | 17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one | n-cyclopropylmethyl-14-hydroxydihydromorphinone | n-cyclopropylmethylnoroxymorphone | naltrexon | naltrexona | naltrexone | naltrexonum

Drug Sentece Context

Table 1. Analysis of context sentence of naltrexone gene in 6 abstracts.

pmid sentence
32930058 Herein, we report that the FDA-approved non-peptide opioid antagonist drug, naltrexone suppresses high fat/LPS induced pro-inflammatory cytokine release both from macrophage cells and Adipose Tissue Macrophage. […] Moreover, Low Dose Naltrexone (LDN) also showed its activity as an ERK1/2 inhibitor. […] Clinical toxicity measurements may not be required for LDN since naltrexone was previously tested and is an approved drug by the FDA.
33221267 Among prescription medications, antidepressants and anti-anxiety medications (4) were reported as well as aspirin (1), losartan (1), and low dose naltrexone (1).
33288348 The Franklin County Sheriff’s Office (FCSO), in Greenfield, Massachusetts, is among the first jails nationwide to provide correctional populations with access to all three medications to treat opioid use disorder (MOUD, i.e., buprenorphine, methadone, naltrexone).
33303086 YORS strategies, such as home delivery of extended-release buprenorphine and extended-release naltrexone for OUD, are designed to increase engagement in treatment, but with the COVID-19 pandemic these strategies increase risk of virus exposure and spread to patients and staff entering homes.
33371945 Prior to the COVID-19 pandemic, the Hennepin County Jail in Minneapolis, Minnesota, offered short-term methadone maintenance, buprenorphine initiation and maintenance, and naltrexone initiation and maintenance to all jail residents with moderate to severe opioid use disorder (OUD).
33421802 IQVIA Total Patient Tracker data were used to calculate U.S. monthly numbers of unique patients dispensed buprenorphine, extended-release (ER) intramuscular naltrexone, naloxone, selective serotonin or serotonin-norepinephrine reuptake inhibitors, benzodiazepines, and for comparison, HMG-CoA reductase inhibitors (statins) and angiotensin receptor blockers (ARBs) between January 2019-May 2020. […] Numbers dispensed ER intramuscular naltrexone were significantly below forecasted estimates in March 2020 (-1039; 95 %CI:-1528 to -550), April 2020 (-2139; 95 %CI:-2629 to -1650), and May 2020 (-2498; 95 %CI:-2987 to -2009).
33483222 A 2018 law (Chapter 208) made Massachusetts (MA) the first state to mandate that five county jails deliver all FDA-approved MOUDs (naltrexone [NTX], buprenorphine [BUP], and methadone).