DrugBank ID: db01043
DrugCentral: memantine
Synonymous :1-amino-3,5-dimethyladamantane | 1,3-dimethyl-5-adamantanamine | 3,5-dimethyl-1-adamantanamine | 3,5-dimethyl-1-aminoadamantane | 3,5-dimethyltricyclo(,7))decan-1-amine | memantina | memantine | memantinum

Drug Sentece Context

Table 1. Analysis of context sentence of memantine gene in 5 abstracts.

pmid sentence
32388458 They were receiving treatment with either amantadine (n=15) or memantine (n=7) in stable registered doses.
32436995 Memantine, a moderate affinity, uncompetitive N-Methyl-D-aspartic acid (NMDA) receptor antagonist which prevents excess calcium entry into cells is commonly utilized in treating patients with Alzheimer’s disease, and may inhibit the neurotoxicity induced by SARS-CoV-2 in the medullary brain stem to avoid development of ARDS. […] Memantine and related adamantine such as amantadine, which is utilized in Parkinson’s disease and influenza, may have some anti-viral potential as well. […] Memantine and similar adamantines may have potential as repurposed medicines for treating Covid19 with inhibition of neurotoxicity, ARDS and viral replication, since Memantine appears to be lysosomotropic.
32662982 Furthermore, some calcium channel blockers (CCBs), such as nimodipine, memantine, etc., have been reported to be effective in the treatment of dementia in Alzheimer’s disease (AD) as well as have shown inhibition in various virus infections.
32828269 The results of a screening effort involving a repurposing drug library of ion channel blockers yielded two compounds that inhibit the E protein: Gliclazide and Memantine.
33182350 We have reviewed current data on the anti-inflammatory effects of amantadine and memantine in clinical and in vivo models of inflammation, and we propose that these effects have potential interest for the treatment of the SARS-CoV-2 infection (COVID-19 disease). […] To that end, we performed a literature search using the PubMed Database from 1966 up to October 31 2020, crossing the terms “amantadine” and “memantine” with “inflammation” and “anti-inflammatory”. […] Amantadine and/or memantine have shown anti-inflammatory effects in chronic hepatitis C, in neuroinflammation induced by sepsis and by lipopolysaccharides, experimental models of multiple sclerosis, spinal cord injury, and respiratory diseases. […] Since the inflammatory response is one of the main pathogenetic mechanisms in the progression of the SARS-CoV-2 infection, anti-inflammatory effects of amantadine and memantine could be hypothetically useful in the treatment of this condition.