ISOLEUCINE


DrugBank ID: db00167
DrugCentral: isoleucine
Synonymous :(2s,3s)-2-amino-3-methylpentanoic acid | 2-amino-3-methylvaleric acid | alpha-amino-beta-methylvaleric acid | ile | isoleucina | isoleucine | isoleucinum | l-isoleucine | α-amino-β-methylvaleric acid



Drug Sentece Context


Table 1. Analysis of context sentence of isoleucine gene in 1 abstracts.

pmid sentence
32083328 Position 723 in the COVID-2019 has a serine instead a glycine residue, while at aminoacidic position 1010 a proline instead an isoleucine.
32378705 At this site, arginine (a positively charged amino acid) was replaced by isoleucine (a hydrophobic amino acid that is also a C-β branched amino acid).
32488835 Through this paper, we provided the list of possible chemical ligands (Meglumine, Vidarabine, Adenosine, D-Sorbitol, D-Mannitol, Sodium_gluconate, Ganciclovir and Chlorobutanol) and peptide drugs (combination of isoleucine, lysine and proline) from the databases to guide the experimental scientists and validate the molecules which can combat the virus in a shorter time.
33453245 Pathway and network enrichment analyses revealed that the 92 DEPs were mostly associated with metabolic, complement and coagulation cascades, lysosome, and cholesterol metabolism pathways, and the 375 COVID-19 only proteins were mainly enriched in amino acid degradation (Valine, Leucine and Isoleucine degradation), amino acid metabolism (beta-Alanine, Tryptophan, Cysteine and Methionine metabolism), oxidative phosphorylation, phagosome, and cholesterol metabolism pathways.