DrugCentral: inh
Synonymous : None

Drug Sentece Context

Table 1. Analysis of context sentence of inh gene in 4 abstracts.

pmid sentence
32531085 Based on the analysis of publicly available interactomes, we propose that SARS-CoV-2 infection directly causes a deficiency in C1 esterase inhibitor (C1-INH), a pathogen-specific mechanism that may help explain significant systemic abnormalities in COVID-19 patients.
32569491 The present research aimed to determine the relation between the use of angiotensin-converting enzyme inhibitors (ACE inh) and angiotensinogen receptor blockers (ARBs) and in-hospital mortality of hypertensive patients diagnosed with Covid-19 pneumonia. […] All patients were on ACE inh/ARBs or other antihypertensive therapy unless no contraindication was present. […] In total, 113 hypertensive Covid-19 patients were included, of them 74 patients were using ACE inh/ARBs. […] The frequency of admission to the ICU and endotracheal intubation were significantly higher in patients using ACE inh/ARBs. […] In a multivariable analysis, the use of ACE inh/ARBs was an independent predictor of in-hospital mortality (OR: 3.66; 95%CI: 1.11-18.18; p= .032). […] Kaplan-Meir curve analysis displayed that patients on ACE inh/ARBs therapy had higher incidence of in-hospital death than those who were not. […] The present study has found that the use of ACE inh/ARBs therapy might be associated with an increased in-hospital mortality in patients who were diagnosed with Covid-19 pneumonia. […] It is likely that ACE inh/ARBs therapy might not be beneficial in the subgroup of hypertensive Covid-19 patients despite the fact that there might be the possibility of some unmeasured residual confounders to affect the results of the study.
33437888 Father and son, as well as another unrelated COVID-19 patient, displayed a robust increase of SERPING1, the transcript encoding C1 esterase inhibitor (C1-INH). […] We further bolstered this finding by incorporating a serum proteomics dataset and found that serum C1-INH was consistently increased in COVID-19 patients. […] C1-INH is a central regulator of the contact and complement systems, potentially linking COVID-19 to complement hyperactivation, fibrin clot formation, and immune depression.