DrugBank ID: db00693
DrugCentral: fluorescein
Synonymous :3,6-fluorandiol | 3’,6’-dihydroxyfluoran | 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone | 9-(o-carboxyphenyl)-6-hydroxy-3h-xanthen-3-one | c.i. solvent yellow 94 | d and c yellow no. 7 | d&c yellow no. 7 | fluoresceina | fluoresceína | fluoresceine | fluoreszein | japan yellow 201 | resorcinolphthalein | solvent yellow 94 | yellow fluorescein

Drug Sentece Context

Table 1. Analysis of context sentence of fluorescein gene in 40 abstracts.

pmid sentence
32243678 Aerosolization was simulated in a cadaver using fluorescein solution (0.2mg/10ml) and quantified using a blue-light filter and digital image processing. […] Surgical aerosolization was simulated during non-powered instrumentation, suction microdebrider, and high-speed drilling following nasal fluorescein application.
32358853 Fluorescein was applied to the surgical field. […] Black light examination of fluorescein-treated operative fields revealed minimal contamination distant to the surgical field.
32384377 Mastoidectomy with a high-speed drill was simulated using fresh-frozen cadaveric heads with fluorescein solution injected into the mastoid air cells.
32423283 After instilling cadaver head specimens (n = 2) with fluorescein solution, endoscopic endonasal procedures were systematically performed to evaluate the quantity, size, and distance of droplets and splatter following each experimental condition. […] There were no observable fluorescein droplets or splatter noted in the measured surgical field in any direction after nasal endoscopy, septoplasty with microdebrider-assisted turbinoplasty, cold-steel functional endoscopic sinus surgery (FESS), and all experimental conditions using an ultrasonic aspirator.
32423287 Fluorescein was instilled through a 4-mm burr hole drilled into the middle cranial fossa floor, and presence in the middle ear was confirmed via microscopic ear examination. […] There were no fluorescein droplets or splatter contamination observed in the measured surgical field in any direction after myringotomy and insertion of ventilation tube.
32457134 A fluorescein dye experiment was used to demonstrate the reduction in aerosol emission output from the bottle with our described technique, allowing an antiviral filter to be attached to a pleural underwater seal drainage bottle for added protection of patients and staff in the local environment.
32497852 Intranasal local application of fluorescein aided in the detection of the direction of flow of the CSF leakage.
32513045 A series of simulated coughs were created with bursts of fluorescein dye through an atomizer tip placed within the test participant’s mouth. […] Fluorescein dye is easily aerosolized along the lateral inferior aspect of a standard shield with significant contamination of the surrounds.
32591652 Spread of patient secretions and droplet formation was evaluated using 1% fluorescein dye in 10 ml of normal saline and ultraviolet light. […] Presence of fluorescein was identified around the patients’ nares; on the chest wipe and instrument tray in all four patients.
32603849 Fluorometric analysis of deposited fluorescein particles on the personal protective equipment of an HCW revealed that negative pressure reduces particle deposition both outside and inside the hood.
32692666 In presence of FITC (fluorescein)-/digoxin- and biotin-labeled primers, mRT-LAMP produced numerous FITC-/digoxin- and biotin-attached duplex amplicons, which were determined by LFB through immunoreactions (FITC/digoxin on the duplex and anti-FITC/digoxin on the test line of LFB) and biotin/treptavidin interaction (biotin on the duplex and strptavidin on the polymerase nanoparticle).
32707426 Patterns of exposure of bioaerosolized particles produced from a cough between different face shields was evaluated using fluorescein dye.
32795090 Objectives include (1) comparing vitamin B2, fluorescein, and a commercial fluorescent green dye in terms of particle dispersion pattern, suspension into aerosols and small droplets, and fluorescence in aerosolized form and (2) determining the utility of vitamin B2 as a fluorescent tracer coating the aerodigestive tract mucosa in otolaryngology contamination models. […] Vitamin B2, fluorescein, and a commercial fluorescent dye were aerosolized using a nebulizer and passed through the nasal cavity from the trachea in a retrograde-intubated cadaveric head. […] When fluorescein and the commercial water tracer dye were nebulized, aerosols ≤8.61 µm and ≤2.08 µm respectively were generated, but the collected aerosols did not appear visibly fluorescent. […] Vitamin B2’s reliability as a fluorescent tracer when suspended in aerosols and small droplets ≤14.1 µm and known mucosal safety profile make it an ideal compound compared to fluorescein and commercial water-based fluorescent dyes for use as a safe fluorescent tracer in healthcare contamination models especially with human subjects.
32798323 Two models simulating respiratory droplets >5-10 μm and fine respiratory nuclei <5 μm using fluorescein dye and wood smoke, respectively, were utilized in a fixed cadaveric study in a controlled environment. […] Using ultraviolet light, fluorescein droplet spread was assessed during simulated ESS with powered microdebrider and powered drilling.
32808872 After completion of a nasal symptom questionnaire, topical fluorescein spray was administered into the nasal and oropharynx of 10 healthy volunteers, who then underwent flexible laryngoscopy under 2 conditions: routine without provoked response and with prompted sneeze/cough.
32873584 Fluorescein was ejected from inside the manikin’s mouth to simulate droplet and contact spread during a standard intubation sequence.
32911957 A cadaveric temporal bone was used to simulate droplet spread during suctioning of fluorescein-labelled middle ear fluid and visualized with a blue-light filter.
32912226 Future studies are needed to better understand the involvement of the microvasculature in coronavirus neuropathology, and to test the diagnostic potential of minimally-invasive screening tools (e.g. serum biomarkers, fluorescein retinal angiography and dynamic-contrast MRI).
32925848 Mastoidectomy with a high-speed drill was simulated using fresh-frozen cadaveric heads with fluorescein solution injected into the mastoid air cells.
32947296 Aerosols were modeled using a commercially available fog machine and droplets were modeled with fluorescein dye.
32947358 High speed shadowgraphy, frontal lighting technique and fluorescein analysis were used to detect the possible generation of any droplets and aerosols.
32949452 Fluorescein incorporated into phacoemulsification irrigation fluid identifying microdroplets and spatter. […] Contamination documented using a single-lens reflex camera with a 532 nm narrow bandpass (fluorescein) filter, in-conjunction with a wide-field blue light and flat horizontal laser beam (wavelength 532 nm).
32966633 Fluorescein was introduced into the irrigation reservoirs of a high-speed air-turbine, ultrasonic scaler and 3-in-1 spray, and procedures were performed on a mannequin in triplicate.
33021846 Color fundus photograph showed a yellowish lesion within the macular area, and fluorescein angiography revealed hyperfluorescence on the topography of the macular lesion in both eyes.
33119257 An RMSD cutoff winnowed down the pool to 12, and free energy analysis (MM/PBSA) produced the final selection of 9 drugs: dihydroergotamine, midostaurin, ziprasidone, etoposide, apixaban, fluorescein, tadalafil, rolapitant, and palbociclib.
33138717 The middle ear of whole head specimens was injected with fluorescein (0.2 mg/10 mL) before endoscopic and microscopic epitympanectomy and mastoidectomy. […] Drilling time, droplet proportion, fluorescein intensity, and droplet size were assessed for every procedure. […] The mean (SD) proportion of fluorescein droplets was 0.14‰ (0.10‰) for endoscopic epitympanectomy and 0.64‰ (0.31‰) for microscopic epitympanectomy.
33186853 The soft tissue of the bilateral mandible and midface of two fresh frozen cadaveric specimens was infiltrated using a 0.1% fluorescein solution.
33191442 The physical barrier effect was measured using fluorescein atomization in a head model. […] The physical barrier effect achieved a 72% reduction in the splatter created from the fluorescein atomization.
33263988 Comparison of virus titration results to reverse transcriptase quantitative PCR and measurement of fluorescein concentrations (doped into the nebulized aerosol) reveals that the reduction in viable PRCV is primarily due to UV-C based inactivation, as opposed to physical collection of virus.
33267645 Multimodal imaging including fluorescein angiography, indocyanine-green angiography, fundus autofluorescence and optical coherence tomography was consistent with serpiginous choroiditis.
33315602 Aerosols were modeled using a commercially available fog machine, and droplets were modeled with fluorescein dye.
33353419 After 1 month of the COVID-19 treatment, fundus examination improved and fluorescein angiography demonstrated no diabetic retinopathy signs, no retinal vasculitis and no significant delay in arterial or venous filling.
33359041 In two experimental designs using simulated dental procedures on a mannequin, fluorescein dye was introduced: (1) into the irrigation system of an air-turbine handpiece; (2) into the mannequin’s mouth. […] Filter papers were placed in an open plan clinic to collect fluorescein. […] In the most realistic model (fluorescein in mouth, medium volume suction), samples in distant bays (≥5 m head-to-head chair distance) gave very low or zero readings (< 0.0016% of the fluorescein used during the procedure).
33414542 The aim of this study was to evaluate splatter and/or settled aerosol contamination during orthodontic debonding.Material and methods Fluorescein dye was introduced into the oral cavity of a mannequin.
33425228 Fluorescein dye was incorporated into the coolant reservoir in order to visualize the production of aerosols during each procedure. […] In group 1, the contaminated surface area covered with fluorescein dye reached 77.3% (1349 cm2) of the total; in group 2 (laser with 80% water) we observed 7.3% (128 cm2) and in group 3 (laser with 40% water) it was 3.8% (68 cm2).
33493263 Herein, by using in silico simulation, co-immunoprecipitation, fluorescence resonance energy transfer, fluorescein isothiocyanate labelling, and rational design of antagonist peptides, we demonstrate that kidney injury molecule-1 (KIM1), a molecule dramatically upregulated upon kidney injury, binds with the receptor-binding domain of SARS-CoV-2 and facilitates its attachment to cell membrane, with the immunoglobulin variable Ig-like (Ig V) domain of KIM1 playing a key role in this recognition.
33544701 Healthy adult volunteers inhaled fluorescein-labeled nebulized 0.5-5μm airborne aerosol or atomized larger aerosolized droplets (30-100μm).
33549768 Fluorescein staining reveals microscopic droplets. […] Fluorescein stained ‘secretions’ were projected onto a series of calibrated targets. […] Accurate mapping droplet spread in clinical environments is possible using fluorescein staining and image analysis.
33583231 Fluorescein angiography illustrated no perfusion defect.
33590653 Fluorescein droplet spread was assessed following microdebriding and drilling of fluorescein-soaked grapes and bones respectively. […] There were no observable fluorescein droplets or splatter in the measured surgical field after microdebridement of nasal polyps at a specific irrigation rate and suction pressure.