DrugBank ID: db00514
Synonymous :(+)-dextromethorphan | d-methorphan | delta-methorphan | dex | dextromethorfan | dextromethorphan | dextrométhorphane | dextromethorphanum | dextrometorfano | dm
Drug Sentece Context
Table 1. Analysis of context sentence of dextromethorphan gene in 2 abstracts.
|32281695||We identified many cheap, available, and safe medicines, such as diphenidol, quinine, chloroquine, artemisinin, chlorpheniramine, yohimbine, and dextromethorphan, which may target the most common symptoms caused by 2019-nCoV.|
|32965508||The antipsychotic drug, haloperidol, exerts remarkable antiviral activity, but, at the same time, the sigma-1 benzomorphan agonist, dextromethorphan, showed pro-viral activity. […] To explore the potential mechanisms of biased binding and activity of the two drugs, haloperidol and dextromethorphan towards NSP6, we herein utilized molecular docking-based molecular dynamics simulation studies. […] Our extensive analysis of the protein-drug interactions, structural and conformational dynamics, residual frustrations, and molecular switches of NSP6-drug complexes indicates that dextromethorphan binding leads to structural destabilization and increase in conformational dynamics and energetic frustrations. […] •Dextromethorphan, agonist of sigma receptors, binding leads to overall destabilization of NSP6.|