CIDOFOVIR
DrugBank ID: db00369
DrugCentral: cidofovir
Synonymous :({[(s)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid | (s)-(3-(4-amino-2-oxopyrimidin-1(2h)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid | (s)-1-(3-hydroxy-2-phosphonomethoxypropyl)cytosine | (s)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine | (s)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine | (s)-hpmpc | [(s)-2-(4-amino-2-oxo-2h-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid | [[(s)-2-(4-amino-2-oxo-1(2h)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid | 1-(s)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine | 1-[(s)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine | cdv | cidofovir | cidofovir anhydrous | cidofovirum
Drug Sentece Context
Table 1. Analysis of context sentence of cidofovir gene in 2 abstracts.
| pmid | sentence |
|---|---|
| 32562705 | While all 11 molecules tested displayed incorporation, 6 exhibited immediate termination of the polymerase reaction (triphosphates of Carbovir, Ganciclovir, Stavudine and Entecavir; 3’-OMe-UTP and Biotin-16-dUTP), 2 showed delayed termination (Cidofovir diphosphate and 2’-OMe-UTP), and 3 did not terminate the polymerase reaction (2’-F-dUTP, 2’-NH2-dUTP and Desthiobiotin-16-UTP). […] Prodrugs of five of these nucleotide analogues (Cidofovir, Abacavir, Valganciclovir/Ganciclovir, Stavudine and Entecavir) are FDA-approved medications for treatment of other viral infections, and their safety profiles are well established. |
| 32834922 | Compared to the other nine medicines, brincidofovir, an ether lipid ester analog of cidofovir with potent antiviral activity, showed the highest docking scores and binding interactions. |
| 33594342 | Among these drugs, in terms of least binding energy, Indinavir, Sorivudine, Cidofovir, and Darunavir showed minimum docking scores with all the key proteins. |