DrugBank ID: db00972
DrugCentral: azelastine
Synonymous :4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinone | azelastina | azelastine | azélastine | azelastinum

Drug Sentece Context

Table 1. Analysis of context sentence of azelastine gene in 2 abstracts.

pmid sentence
32308266 We further report that Conivaptan and Azelastine are mainly involved in hydrophobic interactions with active site residues.
33309272 Usage of diphenhydramine, hydroxyzine and azelastine was associated with reduced incidence of SARS-CoV-2 positivity in subjects greater than age 61. […] We found diphenhydramine, hydroxyzine and azelastine to exhibit direct antiviral activity against SARS-CoV-2 in vitro. […] Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets. […] Clinical studies are needed to measure the effectiveness of diphenhydramine, hydroxyzine and azelastine for disease prevention, for early intervention, or as adjuvant therapy for severe COVID-19.