DrugBank ID: db00972
Synonymous :4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinone | azelastina | azelastine | azélastine | azelastinum
Drug Sentece Context
Table 1. Analysis of context sentence of azelastine gene in 2 abstracts.
|32308266||We further report that Conivaptan and Azelastine are mainly involved in hydrophobic interactions with active site residues.|
|33309272||Usage of diphenhydramine, hydroxyzine and azelastine was associated with reduced incidence of SARS-CoV-2 positivity in subjects greater than age 61. […] We found diphenhydramine, hydroxyzine and azelastine to exhibit direct antiviral activity against SARS-CoV-2 in vitro. […] Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets. […] Clinical studies are needed to measure the effectiveness of diphenhydramine, hydroxyzine and azelastine for disease prevention, for early intervention, or as adjuvant therapy for severe COVID-19.|