APREMILAST
DrugBank ID: db05676
DrugCentral: apremilast
Synonymous :apremilast | aprémilast | apremilastum | n-{2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1h-isoindol-4-yl}acetamide
Drug Sentece Context
Table 1. Analysis of context sentence of apremilast gene in 8 abstracts.
| pmid | sentence |
|---|---|
| 32385859 | Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur. |
| 32458536 | Apremilast, acitretin and dupilumab, have favorable safety data, and may be safely initiated and continued in uninfected patients. |
| 32475036 | Apremilast is a recently approved drug, belonging to the small molecule phosphodiesterase 4 inhibitors, whose optimal safety and efficacy profile is somewhat affected by slow activity rate in clinical trials. […] Moreover, the observation period includes the Italian outbreak of COVID-19 epidemic, and further information on apremilast safety are provided, no one of the patients having stopped treatment. […] In such a critical period, the apremilast satisfactory speed of therapeutic response in a real-world setting has further strengthens patient’s compliance to remain safely at home, which is the best strategy to limit contagion. |
| 32618402 | The patient infected with COVID-19 on apremilast and the one on apremilast with infected spouse showed the best safety profile and mildest symptoms. […] Even though more clinical data are yet needed to draw strong conclusions, apremilast could be a safer alternative for dermatology and rheumatology patients in case of clinically important active infection. |
| 32931985 | Available data suggest no increased frequency or risk of respiratory viral events with NSAIDs, hydroxychloroquine, sulfasalazine, methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide, or apremilast. |
| 33141519 | For psoriatic patients with comorbidities switching to safer modalities such as systemic retinoids, apremilast, and home phototherapy is recommended. |