DrugBank ID: db06742
DrugCentral: ambroxol
Synonymous :ambroxolum | bisolvon metabolite viii | bromhexine metabolite viii | bromhexine-metabolite viii | cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (e)- | n-(2-amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol | n-(2-amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol | trans-4-((2-amino-3,5-dibromobencil)amino)ciclohexanol | trans-4-((2-amino-3,5-dibromobenzyl)amine)cyclohexanol | trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol

Drug Sentece Context

Table 1. Analysis of context sentence of ambroxol gene in 6 abstracts.

pmid sentence
32741259 Based on better dock score, binding-free energy and binding interactions compared to the control molecules, six molecules (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) were found to be promising against the TMPRSS2.
33045350 This paper highlights the potential of azithromycin and ambroxol to treat COVID-19. […] Azithromycin and ambroxol share lysosomotropic characteristics, i.e. they penetrate and accumulate inside the late endosomes and lysosomes and may possibly interfere with multiplication of the virus inside cells. […] Ambroxol has a proven antiviral effect and a unique stimulatory action on the secretion of surfactant by alveolar type II cells, the main target of SARS-CoV-2.
33102461 This hypothesis proposes aerosolized surfactant delivery taking the optimal dosing and coating costs into account along with co-delivery of ambroxol to provide synergistic benefits. […] Ambroxol is reported to have anti-inflammatory, -oxidant, -viral, and -bacterial activities and has a direct impact on the production and secretion of the surfactant from the alveolar Type 2 cells. […] If aerosolized, atomized, or nebulized in the form of ambroxol-loaded phospholipid nanovesicles at the early stages of ARDS, depleted surfactant levels may be reinstated and surfactant turnover can be initiated and maintained. […] In conclusion, the surfactant-ambroxol co-aerosolized intervention approach hypothesized here has implications reaching to clinical and pharmaceutical translation worldwide.
33181718 In addition, we found that the application rates of large doses of ambroxol (P = .043) and prone-position drainage (P = .037) were relatively high in COVID-19 patients with good prognoses, suggesting that the early application of large doses of expectorant drugs and prone-position drainage in COVID-19 patients may avoid progression to critical illness and improve the prognosis.
33290446 Nine patients were prescribed systemic prednisone and nasal irrigation with betamethasone, ambroxol and rinazine for 15 days.