DrugBank ID: db04705
DrugCentral: 25-hydroxycholesterol
Synonymous :5-cholestene-3beta,25-diol | cholest-5-ene-3beta,25-diol

Drug Sentece Context

Table 1. Analysis of context sentence of 25-hydroxycholesterol gene in 2 abstracts.

pmid sentence
32532085 In addition to remdesivir, lopinavir, and chloroquine, our primary screening additionally identified types I and II recombinant interferons, 25-hydroxycholesterol, and AM580 as the most potent anti-SARS-CoV-2 agents among the 22 antiviral agents. […] The lipogenesis modulators 25-hydroxycholesterol and AM580 exhibited EC50 at low micromolar levels and selectivity indices of >10.0.
32810737 Moreover, no correlation at all was observed between 24-hydroxycholesterol and 25-hydroxycholesterol serum levels and the severity of the disease.
33239446 Here, using an IFN-stimulated gene screen against vesicular stomatitis virus (VSV)-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identified CH25H and its enzymatic product 25-hydroxycholesterol (25HC) as potent inhibitors of SARS-CoV-2 replication.